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Review
. 2025 May 29;38(4):113.
doi: 10.1007/s13577-025-01239-2.

Biological functions and molecular mechanisms of circHIPK3 in digestive system tumors

Jian Li #  1   2 , Xin Su #  1   2 , Xiao Xu #  1   2 , Youbao Ye  1   2 , Cailiu Wang  1   2 , Ang Liu  1   2 , Changchun Zhao  1   2 , Wenxiu Liu  1   2 , Liwen Yang  1 , Tao Wang  3 , Xiangyong Hao  4
Affiliations
Review

Biological functions and molecular mechanisms of circHIPK3 in digestive system tumors

Jian Li et al. Hum Cell. .

Abstract

Digestive system tumors are the most common tumors worldwide with high mortality rates. Circular homeodomain-interacting protein kinase 3 (circHIPK3) is a highly abundant and stable circular RNA and have garnered significant attention in the field of cancer research. This review systematically explores potential of circHIPK3 as a clinical biomarker, clinical significance in pharmacotherapy, and molecular mechanisms that regulate biological functions such as cell proliferation, survival, migration, invasion, epithelial-mesenchymal transition, metabolism and angiogenesis in digestive system tumors. Moreover, this review further explored the influence of circHIPK3 on key signaling pathways and the potential clinical value as a diagnostic biomarker and therapeutic target. By delving into the biological functions and molecular mechanisms of circHIPK3, this review aims to provide novel research directions and theoretical guidance for the identification of new therapeutic targets and the development of individualized treatment protocols for digestive system tumors.

Keywords: Biomarker; CircHIPK3; Digestive system tumor; Molecular mechanism; Therapeutic target.

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Conflict of interest statement

Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose. Ethical approval: Not applicable.

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