Biodiversity2Drugs-Renaissance of exploring nature-derived peptides for GPCR ligand discovery

Christian W Gruber¹, Isabel Beets², Pierre-Luc Boudreault³, Vanderlan da S Bolzani⁴, Jens Carlsson⁵, Pedro A Fernandes⁶, Michael Freissmuth¹, Nicolas Gilles⁷, Ulf Göransson⁸, Alexander S Hauser^{9

10}, Christian Heinis¹¹, Jeroen Kool¹², William D Lubell¹³, Maria Vittoria Modica¹⁴, Jana Selent¹⁵, Jan Tytgat¹⁶, Eivind A B Undheim¹⁷; Biodiversity2Drugs Consortium

Collaborators, Affiliations

Collaborators

Biodiversity2Drugs Consortium:
Christian W Gruber¹⁸, Michael Freissmuth¹⁸, Nicolas Gilles¹⁹, Marion Chaigneau¹⁹, Xavier Iturrioz¹⁹, Pascal Kessler¹⁹, Philippe Robin¹⁹, Isabel Beets²⁰, Eivind A B Undheim¹⁷, Jeroen Kool¹², Rob Leurs¹², Henry Vischer¹², Jan Tytgat²⁰, Steve Peigneur²⁰, Kathleen Carleer²⁰, Vanderlan da S Bolzani²¹, Ana Leticia Piros²¹, William Lubell²², Pierre-Luc Boudreault²³, Alexander S Hauser²⁴, Luuk R Hoegen Dijkhof²⁴, Teemu K E Rönkkö²⁴, Maria Vittoria Modica¹⁴, Serena Leone¹⁴, Giovanna Ponte¹⁴, Pedro Fernandes²⁵, Maria Joao Ramos²⁵, Jana Selent¹⁵, Elizaveta Korchevaya¹⁵, Tomasz Stepniewski¹⁵, Jens Carlsson²⁶, Israel Cabeza de Vaca²⁶, Ulf Göransson²⁶, Sunithi Gunasekera²⁶, Erik Jacobsson²⁶, Christian Heinis²⁷, Tao Che²⁸, Maurice R Elphick²⁹, Peter J McCormick³⁰, Samuel Robinson³¹, Helena Safavi-Hemami³², Roderich D Süssmuth³³, Axel Touchard³⁴, Wilfred A van der Donk³⁵, Denise Wootten³⁶, Julius Hermes¹, Johannes Schneider¹², Ana Leticia Pires⁴, Marin Matic⁹, António J M Ribeiro⁶, João Sousa⁶, Joana Ribeiro da Silva⁶, Lauri Urvas⁵, Arun Shukla³⁷

Affiliations

¹ Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
² Unit of Animal Physiology and Neurobiology, KU Leuven, Leuven, Belgium.
³ Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Canada.
⁴ Institute of Chemistry, São Paulo State University, São Paulo, Brazil.
⁵ Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
⁶ LAQV-REQUIMTE, Faculty of Sciences, University of Porto, Porto, Portugal.
⁷ CEA, Département Médicaments et Technologies pour la Santé, SIMoS, Université Paris Saclay, Gif-sur-Yvette, France.
⁸ Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
⁹ Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
¹⁰ Center for Pharmaceutical Data Science Education, University of Copenhagen, Copenhagen, Denmark.
¹¹ Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
¹² Faculty of Science, Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
¹³ Département de Chimie, Université de Montréal, Montreal, Canada.
¹⁴ Stazione Zoologica Anton Dohrn, Naples, Italy.
¹⁵ Hospital del Mar Research Institute, Barcelona, Spain.
¹⁶ Unit of Toxicology and Pharmacology, KU Leuven, Leuven, Belgium.
¹⁷ Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, Oslo, Norway.
¹⁸ Medical University of Vienna, Vienna, Austria.
¹⁹ Université Paris Saclay & Commissariat à l'énergie atomique et aux énergies alternatives CEA, Paris, France.
²⁰ KU Leuven, Leuven, Belgium.
²¹ Sao Paulo State University, São Paulo, Brazil.
²² Université de Montréal, Montreal, Canada.
²³ Université de Sherbrooke, Sherbrooke, Canada.
²⁴ University of Copenhagen, Copenhagen, Denmark.
²⁵ LAQV-REQUIMTE, University of Porto, Porto, Portugal.
²⁶ Uppsala University, Uppsala, Sweden.
²⁷ Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
²⁸ Washington University in St. Louis, St. Louis, Missouri, USA.
²⁹ Queen Mary University of London, London, UK.
³⁰ University of Liverpool, Liverpool, UK.
³¹ Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
³² Department of Biochemistry, University of Utah, Salt Lake City, Utah, USA.
³³ Technische Universität Berlin, Berlin, Germany.
³⁴ CNRS, Paris, France.
³⁵ University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.
³⁶ Monash Institute of Pharmaceutical Sciences, Parkville, Australia.
³⁷ Indian Institute of Technology Kanpur, India.

PMID: 40442894
DOI: 10.1111/bph.70072

Biodiversity2Drugs-Renaissance of exploring nature-derived peptides for GPCR ligand discovery

Christian W Gruber et al. Br J Pharmacol. 2025 Aug.

. 2025 Aug;182(16):3691-3694.

doi: 10.1111/bph.70072. Epub 2025 May 29.

Authors

Collaborators

Biodiversity2Drugs Consortium:
Christian W Gruber¹⁸, Michael Freissmuth¹⁸, Nicolas Gilles¹⁹, Marion Chaigneau¹⁹, Xavier Iturrioz¹⁹, Pascal Kessler¹⁹, Philippe Robin¹⁹, Isabel Beets²⁰, Eivind A B Undheim¹⁷, Jeroen Kool¹², Rob Leurs¹², Henry Vischer¹², Jan Tytgat²⁰, Steve Peigneur²⁰, Kathleen Carleer²⁰, Vanderlan da S Bolzani²¹, Ana Leticia Piros²¹, William Lubell²², Pierre-Luc Boudreault²³, Alexander S Hauser²⁴, Luuk R Hoegen Dijkhof²⁴, Teemu K E Rönkkö²⁴, Maria Vittoria Modica¹⁴, Serena Leone¹⁴, Giovanna Ponte¹⁴, Pedro Fernandes²⁵, Maria Joao Ramos²⁵, Jana Selent¹⁵, Elizaveta Korchevaya¹⁵, Tomasz Stepniewski¹⁵, Jens Carlsson²⁶, Israel Cabeza de Vaca²⁶, Ulf Göransson²⁶, Sunithi Gunasekera²⁶, Erik Jacobsson²⁶, Christian Heinis²⁷, Tao Che²⁸, Maurice R Elphick²⁹, Peter J McCormick³⁰, Samuel Robinson³¹, Helena Safavi-Hemami³², Roderich D Süssmuth³³, Axel Touchard³⁴, Wilfred A van der Donk³⁵, Denise Wootten³⁶, Julius Hermes¹, Johannes Schneider¹², Ana Leticia Pires⁴, Marin Matic⁹, António J M Ribeiro⁶, João Sousa⁶, Joana Ribeiro da Silva⁶, Lauri Urvas⁵, Arun Shukla³⁷

Affiliations

¹ Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
² Unit of Animal Physiology and Neurobiology, KU Leuven, Leuven, Belgium.
³ Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Canada.
⁴ Institute of Chemistry, São Paulo State University, São Paulo, Brazil.
⁵ Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
⁶ LAQV-REQUIMTE, Faculty of Sciences, University of Porto, Porto, Portugal.
⁷ CEA, Département Médicaments et Technologies pour la Santé, SIMoS, Université Paris Saclay, Gif-sur-Yvette, France.
⁸ Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
⁹ Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
¹⁰ Center for Pharmaceutical Data Science Education, University of Copenhagen, Copenhagen, Denmark.
¹¹ Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
¹² Faculty of Science, Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
¹³ Département de Chimie, Université de Montréal, Montreal, Canada.
¹⁴ Stazione Zoologica Anton Dohrn, Naples, Italy.
¹⁵ Hospital del Mar Research Institute, Barcelona, Spain.
¹⁶ Unit of Toxicology and Pharmacology, KU Leuven, Leuven, Belgium.
¹⁷ Centre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, Oslo, Norway.
¹⁸ Medical University of Vienna, Vienna, Austria.
¹⁹ Université Paris Saclay & Commissariat à l'énergie atomique et aux énergies alternatives CEA, Paris, France.
²⁰ KU Leuven, Leuven, Belgium.
²¹ Sao Paulo State University, São Paulo, Brazil.
²² Université de Montréal, Montreal, Canada.
²³ Université de Sherbrooke, Sherbrooke, Canada.
²⁴ University of Copenhagen, Copenhagen, Denmark.
²⁵ LAQV-REQUIMTE, University of Porto, Porto, Portugal.
²⁶ Uppsala University, Uppsala, Sweden.
²⁷ Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
²⁸ Washington University in St. Louis, St. Louis, Missouri, USA.
²⁹ Queen Mary University of London, London, UK.
³⁰ University of Liverpool, Liverpool, UK.
³¹ Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
³² Department of Biochemistry, University of Utah, Salt Lake City, Utah, USA.
³³ Technische Universität Berlin, Berlin, Germany.
³⁴ CNRS, Paris, France.
³⁵ University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.
³⁶ Monash Institute of Pharmaceutical Sciences, Parkville, Australia.
³⁷ Indian Institute of Technology Kanpur, India.

PMID: 40442894
DOI: 10.1111/bph.70072

No abstract available

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References

REFERENCES

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1. Lorente, J. S., Sokolov, A. V., Ferguson, G., Schiöth, H. B., Hauser, A. S., & Gloriam, D. E. (2025). GPCR drug discovery: new agents, targets and indications. Nature Reviews in Drug Discovery. https://doi.org/10.1038/s41573-025-01139-y
1. Morales, P., Scharf, M. M., Bermudez, M., Egyed, A., Franco, R., Hansen, O. K., Jagerovic, N., Jakubík, J., Keserű, G. M., Kiss, D. J., Kozielewicz, P., Larsen, O., Majellaro, M., Mallo‐Abreu, A., Navarro, G., Prieto‐Díaz, R., Rosenkilde, M. M., Sotelo, E., Stark, H., … Wingler, L. M. (2024). Progress on the development of Class A GPCR‐biased ligands. British Journal of Pharmacology, 1–52. https://doi.org/10.1111/bph.17301

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Biodiversity2Drugs-Renaissance of exploring nature-derived peptides for GPCR ligand discovery

Collaborators

Affiliations

Biodiversity2Drugs-Renaissance of exploring nature-derived peptides for GPCR ligand discovery

Authors

Collaborators

Affiliations

References

REFERENCES

Grants and funding

LinkOut - more resources

Full Text Sources