Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2025 Jun 4;40(6):ivaf127.
doi: 10.1093/icvts/ivaf127.

Clinical assessment of cannula performance during adult minimally invasive valve surgery using predictive mathematical models

Korneel Vandewiele  1 , Filip De Somer  1 , Michael Vandenheuvel  2 , Pascal Verdonck  3 , Thierry Bové  4
Affiliations
Observational Study

Clinical assessment of cannula performance during adult minimally invasive valve surgery using predictive mathematical models

Korneel Vandewiele et al. Interdiscip Cardiovasc Thorac Surg. .

Abstract

Objectives: Peripheral cannula selection in minimally invasive cardiac surgery (MICS) is crucial, as venous drainage limitations during cardiopulmonary bypass (CPB) can impair end-organ perfusion and overall outcomes. This study evaluates the in vivo venous drainage efficiency of different peripheral venous cannulas for adult MICS by applying dynamic similarity (DS) prediction formulas.

Methods: This observational study included 75 adult MICS patients with use of single peripheral venous cannulation from January 2017 to June 2023. The analysis included cannulas Bio-Medicus Multi XL Life Support, Nextgen Bicaval and Smart cannulas. Cannula performance was assessed by comparing predicted pressures with in vivo measurements.

Results: A total of 278, 314 and 264 measurements were recorded for the Multi, Next and Smart cannulas, respectively. No significant demographic differences were found between groups. Lin's concordance correlation coefficients for agreement between predicted and measured pressures were >0.95 for the Multi and Next cannulas but substantially lower for the Smart cannula (0.80). Bland-Altman analysis showed a mean bias of -1.09 mmHg for the Multi, -0.15 mmHg for the Next and 3.68 mmHg for the Smart cannula, with the latter exceeding the ±12.5 mmHg limits of agreement.

Conclusions: DS-based predictions revealed significant performance variability among peripheral venous cannula types. The in vivo performance was adequately predicted for the Multi and Next cannulas but not for the Smart cannula, underscoring the need for real-life evaluations and performance monitoring during CPB. Incorporating dynamic performance assessments into clinical decision-making might optimize venous drainage and patient outcomes.

Keywords: ECMO; cannula performance; cardiopulmonary bypass; dynamic similarity; minimally invasive cardiac surgery; venous drainage.

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

None
Graphical abstract
Figure 1:
Figure 1:
The venous drainage system with associated pressure levels. CP: centrifugal pump; HD: height difference between CPB pressure transducer and patient’s mid-axillary line; HLM: heart lung machine; CVP: central venous pressure
Figure 2:
Figure 2:
Bland-Altman plots for the groups stratified with (A–C) and without (D–F) atrial retraction. M: measured; P: predicted
Figure 3:
Figure 3:
Predicted versus measured cannula resistances stratified for type and diameter
See this image and copyright information in PMC

References

    1. Vandewiele K, De Somer F, Vandenheuvel M, Philipsen T, Bove T. The impact of cardiopulmonary bypass management on outcome: a propensity matched comparison between minimally invasive and conventional valve surgery. Interact Cardiovasc Thorac Surg 2020;31:48–55. doi: 10.1093/icvts/ivaa052 - DOI - PubMed
    1. De Somer F, Taeymans Y, De Wachter D, Verdonck P, Van Nooten G. Prediction of the clinical performance of adult arterial cannulas. Artif Organs 2004;28:655–9. doi: 10.1111/j.1525-1594.2004.07373.x - DOI - PubMed
    1. Ganushchak YM, Kurniawati ER, Maessen JG, Weerwind PW. Peripheral cannulae selection for veno-arterial extracorporeal life support: a paradox. Perfusion 2020;35:331–7. doi: 10.1177/0267659119885586 - DOI - PMC - PubMed
    1. Simons AP, Ganushchak Y, Wortel P et al. Laboratory performance testing of venous cannulae during inlet obstruction. Artif Organs 2008;32:566–71. doi: 10.1111/j.1525-1594.2008.00584.x - DOI - PubMed
    1. De Somer F. Strategies for Optimisation of Paediatric Cardiopulmonary Bypass. Rijksuniversiteit Groningen, The Netherlands: Shaker Publications, 2003.

Publication types

MeSH terms