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. 2025 May 25:17:985-996.
doi: 10.2147/CMAR.S527496. eCollection 2025.

The Naples Prognostic Score Exerts a Significant Impact on the Prognosis of Patients Diagnosed with External Auditory Canal Carcinoma After Surgery

Xue-Lian Xu  1 , Hao Cheng  1   2 , Xin-Meng Wu  1 , Jin-Hong Xu  3
Affiliations

The Naples Prognostic Score Exerts a Significant Impact on the Prognosis of Patients Diagnosed with External Auditory Canal Carcinoma After Surgery

Xue-Lian Xu et al. Cancer Manag Res. .

Abstract

Background: External auditory canal carcinoma (EACC) is a rare malignant tumor. This study aimed to investigate the influence of the comprehensive index of nutrition- Naples prognostic score (NPS) on the prognosis of EACC patients with surgical resection.

Methods: A total of 73 EACC patients with surgical resection were selected from two tertiary medical institutions, and were diagnosed between Sep 2008 and Aug 2019. The univariate and multivariate Cox regression analyses were used to identify the independent prognostic factors for disease-free survival (DFS) and overall survival (OS) for postoperative EACC patients. The prognosis for postoperative EACC patients with varying NPS were displayed by Kaplan-Meier plots.

Results: The 3- and 5-year survival rate for EACC patients with surgical resection were 72.6%, 32.9% for DFS, and 76.7%, 52.1% for OS, respectively. The multivariate Cox regression analysis revealed that advanced Pittsburgh stage, perineural invasion, vascular invasion, and higher NPS were identified as independent prognostic factors for DFS. Additionally, advanced Pittsburgh stage, vascular invasion, an ACCI score of 6 or higher, and higher NPS were found to be independent predictors for OS.

Conclusion: NPS serves as a crucial predictor of postoperative outcomes in patients with EACC, with higher levels indicating poorer disease-free and overall survival. Additionally, factors such as Pittsburgh stage, perineural and vascular invasion, and ACCI are also significant prognostic indicators.

Keywords: Naples prognostic score; disease-free survival; external auditory canal carcinoma; overall survival; prognosis.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The flow chart of the study.
Figure 2
Figure 2
The calculation method of the Naples prognostic score.
Figure 3
Figure 3
The KM curves to predict DFS (A) and OS (B) for patients with varying NPS.
See this image and copyright information in PMC

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