Technical Considerations of Ozonated Oils in Medical Applications: A Narrative Review

Abstract

Ozonated oils, derived from the reaction of ozone with unsaturated fatty acids in vegetable oils such as coconut, olive, sunflower, and sesame, have gained significant attention in medical applications due to their recognized germicidal, immune-stimulating, and tissue-repairing properties. These stabilized ozonated oils release ozone gradually in the form of ozonides, which are stable and capable of providing prolonged therapeutic effects, mainly when applied topically. The germicidal properties of ozonated oils, primarily exerted through the oxidation of microbial cell walls, make them effective in treating various conditions, including skin infections, dermatitis, and fungal infections. Despite ozone's inherent instability, ozonated oils have demonstrated substantial therapeutic efficacy, including bactericidal, fungicidal, and virucidal effects. The clinical use of ozonated oils is expanding, offering a lower-cost, effective alternative to conventional treatments, especially in managing infections resistant to antibiotics. While their primary application remains topical, there is growing evidence of their positive effects when used orally, particularly in enhancing immune function and promoting tissue regeneration. This review examines the technical considerations for the medical application of ozonated oils, focusing on their stability, chemical characteristics, and therapeutic potential.

Keywords: clinical use; conventional treatments; criegee reaction; ozonated oils; quality control.