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Case Reports
. 2025 May 30;44(7):e254-e257.
doi: 10.1097/INF.0000000000004780.

Metagenomics Diagnosis of a Parvovirus B19-Associated Encephalomyelitis in an Epidemic Context

Julien Andréani  1 , Mina Smiljkovic  2 , Elodie Lametery  2 , Syrine Khedimallah  1 , Noémie Court  1 , Hugo Jardin  1 , Julie Arata-Bardet  2 , Aurélie Truffot  1   3 , Raphaele Germi  1   3 , Patrice Morand  1   3 , Pierre Cappy  4 , Christophe Rodriguez  4 , Julien Lupo  1   3 , Sylvie Larrat  1
Affiliations
Case Reports

Metagenomics Diagnosis of a Parvovirus B19-Associated Encephalomyelitis in an Epidemic Context

Julien Andréani et al. Pediatr Infect Dis J. .

Abstract

In the context of increasing parvovirus B19 (B19V) infections, we describe a case of B19V encephalomyelitis without any usually associated clinical features. Etiology was identified by metagenomics and confirmed by PCR and whole-genome sequencing. This case highlights the need to consider the diagnosis of B19V infection in patients presenting with neurological symptoms.

Keywords: encephalomyelitis; metagenomic; parvovirus B19; whole-genome sequencing.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

References

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