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. 2025 Jul;49(7):1899-1902.
doi: 10.1002/wjs.12646. Epub 2025 May 30.

Histotripsy of Pancreatic Cancer Liver Metastases: Early Outcomes and Imaging Findings

Tarub S Mabud  1 , Monica Vergara  1 , Jasper Du  1 , Shu Liu  1 , Frederic Bertino  1 , Bedros Taslakian  1 , Christopher Wolfgang  2 , Mikhail Silk  1 , D Brock Hewitt  2
Affiliations

Histotripsy of Pancreatic Cancer Liver Metastases: Early Outcomes and Imaging Findings

Tarub S Mabud et al. World J Surg. 2025 Jul.

Abstract

Patients with pancreatic ductal adenocarcinoma (PDAC) frequently present with liver metastases, which severely limit treatment options and prognosis. In other cancers, treatment of liver disease can improve outcomes and similar approaches are being explored in PDAC. Clinical data for locoregional control of pancreatic cancer liver metastases (PCLM) are limited, and histotripsy offers a new noninvasive tool for disease control. This study evaluates the preliminary safety, efficacy, and imaging findings of histotripsy in patients with PCLM.

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