Unraveling the effects of radiotherapy on the blood-brain barrier: Fact or fiction?
- PMID: 40445131
- PMCID: PMC12526051
- DOI: 10.1093/neuonc/noaf137
Unraveling the effects of radiotherapy on the blood-brain barrier: Fact or fiction?
Conflict of interest statement
R.K.: Honoraria from Accuray Inc., Elekta AB, ViewRay Inc., Novocure Inc., Elsevier Inc., Brainlab, Kazia Therapeutics, Castle Biosciences, and Ion Beam Applications and institutional research funding from Medtronic Inc., Blue Earth Diagnostics Ltd., Novocure Inc., GT Medical Technologies, AstraZeneca, Exelixis, ViewRay Inc., Brainlab, Cantex Pharmaceuticals, Kazia Therapeutics, and Ion Beam Applications. M.P.M.: Honoraria from AIQ, Chimerix, Kazia, Mevion, Telix; stock in Chimerix.
Comment on
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The impact of therapeutic radiation on drug distribution across the blood-brain barrier in normal mouse brain and orthotopic glioblastoma tumors.Neuro Oncol. 2025 Oct 14;27(9):2250-2261. doi: 10.1093/neuonc/noaf093. Neuro Oncol. 2025. PMID: 40163716 Free PMC article.
References
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- Fang L, Sun X, Song Y, et al. Whole-brain radiation fails to boost intracerebral gefitinib concentration in patients with brain metastatic non-small cell lung cancer: A self-controlled, pilot study. Cancer Chemother Pharmacol. 2015;76(4):873–877. - PubMed
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