Effective use of anti-CD19 chimeric antigen receptor T cells in a case of treatment-resistant granulomatosis with polyangiitis

Luisa Uhlmann¹, Matthias Pierer², Marco Krasselt³, Georg Franke⁴, Robert Zeidler⁵, Osama Sabri⁶, Timm Denecke⁷, Ulrich Sack⁸, Ulrike Köhl⁹, Andreas Boldt¹⁰, Dominic Borie¹¹, Ulf Wagner¹², Uwe Platzbecker¹³, Vladan Vucinic¹⁴

Affiliations

¹ University Leipzig Medical Center, Clinic and Policlinic for Endocrinology, Nephrology and Rheumatology, Leipzig, Germany. Electronic address: luisa.uhlmann@medizin.uni-leipzig.de.
² University Leipzig Medical Center, Clinic and Policlinic for Endocrinology, Nephrology and Rheumatology, Leipzig, Germany.
³ University Leipzig Medical Center, Clinic and Policlinic for Endocrinology, Nephrology and Rheumatology, Leipzig, Germany.
⁴ University Leipzig Medical Center,  Clinic and Policlinic for Hematology,  Cellular Therapy,  Hemostaseology and Infectious Diseases, Leipzig, Germany.
⁵ University Leipzig Medical Center, Department of Clinic and Policlinic for Nuclear Medicine, Leipzig, Germany.
⁶ University Leipzig Medical Center, Department of Clinic and Policlinic for Nuclear Medicine, Leipzig, Germany.
⁷ University Leipzig Medical Center, Clinic and Policlinic for Diagnostic and Interventional Radiology, Leipzig, Germany.
⁸ University Leipzig Medical Center, Institute for Clinical Immunology, Leipzig, Germany.
⁹ University Leipzig Medical Center, Institute for Clinical Immunology, Leipzig, Germany; Fraunhofer IZI, Leipzig, Germany; Cancer Center Central Germany, Leipzig, Germany.
¹⁰ University Leipzig Medical Center, Institute for Clinical Immunology, Leipzig, Germany.
¹¹ Kyverna Therapeutics Inc, Emeryville, CA, United States.
¹² University Leipzig Medical Center, Clinic and Policlinic for Endocrinology, Nephrology and Rheumatology, Leipzig, Germany.
¹³ University Leipzig Medical Center, Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig, Germany; Cancer Center Central Germany, Leipzig, Germany.
¹⁴ University Leipzig Medical Center, Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig, Germany; Cancer Center Central Germany, Leipzig, Germany.

PMID: 40447497
DOI: 10.1016/j.ard.2025.04.029

Effective use of anti-CD19 chimeric antigen receptor T cells in a case of treatment-resistant granulomatosis with polyangiitis

Luisa Uhlmann et al. Ann Rheum Dis. 2025 Jul.

. 2025 Jul;84(7):1280-1283.

doi: 10.1016/j.ard.2025.04.029. Epub 2025 May 29.

Authors

Affiliations

¹ University Leipzig Medical Center, Clinic and Policlinic for Endocrinology, Nephrology and Rheumatology, Leipzig, Germany. Electronic address: luisa.uhlmann@medizin.uni-leipzig.de.
² University Leipzig Medical Center, Clinic and Policlinic for Endocrinology, Nephrology and Rheumatology, Leipzig, Germany.
³ University Leipzig Medical Center, Clinic and Policlinic for Endocrinology, Nephrology and Rheumatology, Leipzig, Germany.
⁴ University Leipzig Medical Center,  Clinic and Policlinic for Hematology,  Cellular Therapy,  Hemostaseology and Infectious Diseases, Leipzig, Germany.
⁵ University Leipzig Medical Center, Department of Clinic and Policlinic for Nuclear Medicine, Leipzig, Germany.
⁶ University Leipzig Medical Center, Department of Clinic and Policlinic for Nuclear Medicine, Leipzig, Germany.
⁷ University Leipzig Medical Center, Clinic and Policlinic for Diagnostic and Interventional Radiology, Leipzig, Germany.
⁸ University Leipzig Medical Center, Institute for Clinical Immunology, Leipzig, Germany.
⁹ University Leipzig Medical Center, Institute for Clinical Immunology, Leipzig, Germany; Fraunhofer IZI, Leipzig, Germany; Cancer Center Central Germany, Leipzig, Germany.
¹⁰ University Leipzig Medical Center, Institute for Clinical Immunology, Leipzig, Germany.
¹¹ Kyverna Therapeutics Inc, Emeryville, CA, United States.
¹² University Leipzig Medical Center, Clinic and Policlinic for Endocrinology, Nephrology and Rheumatology, Leipzig, Germany.
¹³ University Leipzig Medical Center, Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig, Germany; Cancer Center Central Germany, Leipzig, Germany.
¹⁴ University Leipzig Medical Center, Clinic and Policlinic for Hematology, Cellular Therapy, Hemostaseology and Infectious Diseases, Leipzig, Germany; Cancer Center Central Germany, Leipzig, Germany.

PMID: 40447497
DOI: 10.1016/j.ard.2025.04.029

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Conflict of interest statement

Competing interests UW received speaking and lecture fees from Novartis Pharma GmbH and UCB Pharma GmbH. LU received travel support from UCB Pharma GmbH. DB is an employee and shareholder of Kyverna Therapeutics Inc. reports financial support and equipment, drugs, or supplies were provided by Kyverna Therapeutics. VV received speaking and lecture fees from Novartis Pharma GmbH, Kite Pharma Inc, Bristol Myers Squibb Co and Johnson & Johnson MedTech. MK received speaking and lecture fees from Novartis Pharma GmbH, Eli Lilly and Company, UCB Pharma GmbH and GSK. UK received speaking and lecture fees from AstraZeneca, Affimed GmbH, Glycostem Therapeutics BV, GammaDelta Therapeutics Ltd, Zelluna Immunotherapy SA, Miltenyi Biotec Inc, Novartis Pharma GmbH and Bristol Myers Squibb Co.

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Effective use of anti-CD19 chimeric antigen receptor T cells in a case of treatment-resistant granulomatosis with polyangiitis

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Effective use of anti-CD19 chimeric antigen receptor T cells in a case of treatment-resistant granulomatosis with polyangiitis

Authors

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Conflict of interest statement

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