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. 2025 May 30;26(1):270.
doi: 10.1186/s12882-025-04168-2.

Effect of serum magnesium level on carotid intima media thickness in hemodialysis patients

Ali Veysel Kara  1 , Ridvan Ozdemir  2 , Hamza Inan  2 , Beyza Ozerten Ozdemir  3 , Serhat Hayme  4 , Muharrem Said Cosgun  5
Affiliations

Effect of serum magnesium level on carotid intima media thickness in hemodialysis patients

Ali Veysel Kara et al. BMC Nephrol. .

Abstract

Background: We aimed to examine whether serum magnesium level is related to cardiovascular events in hemodialysis patients by investigating the relationship between serum magnesium (Mg) level and carotid intima media thickness (CIMT).

Methods: In this cross-sectional study, we evaluated 88 hemodialysis patients. The mean CIMT of these patients was measured and recorded by doppler ultrasonography. Patients were divided into two groups according to their serum magnesium level. Correlation analysis and linear regression analysis were used to define the relationship between study parameters. We divided our patients into 2 groups according to Mg value as group 1 (Mg ≥ 2.3 mg/dl) and group 2 (Mg < 2.3 mg/dl).

Results: The mean CIMT of patients with group 1 and group 2 were respectively 0.93 ± 0.22 mm and 1.03 ± 0.22 mm. There was statistically significant difference between two groups in terms of the mean CIMT value (p = 0.045). We found negative, low-level, statistically significant correlations between Mg and mean CIMT ​​(r=-0.272; p = 0.010), calcium and mean CIMT (r: -0.221, p: 0.039) and hemoglobin and mean CIMT (r: -0.215, p: 0.044). According to regression analysis, serum magnesium level and age were found independent risk factors for mean CIMT value (p: 0.004 and p: 0.045).

Conclusions: We found a significant relationship between serum Mg level and CIMT, which indicates carotid atherosclerosis.

Keywords: Cardiovascular disease; Carotid intima-media thickness; Hemodialysis; Magnesium.

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Conflict of interest statement

Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Erzincan Binali Yıldırım University Non-Interventional Clinical Research Ethics Committee (Approval Number: 00/2022, 02/7). Written informed consent was obtained from all participants prior to their inclusion in the study. All participants were fully informed about the study’s aims, procedures, potential risks, and their right to withdraw at any time without any consequences. Patient consent statement: Patient consent was taken from all of the patients included in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Scatter plot graphs of the Pearson correlation analysis showing the relationships between (a) hemoglobin and mean CIMT, (b) serum calcium and mean CIMT, and (c) serum magnesium and mean CIMT. CIMT: Carotid intima-media thickness
See this image and copyright information in PMC

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