Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May 30;24(1):618.
doi: 10.1186/s12912-025-03273-9.

Factors influencing sense of coherence in caregivers of children with acute leukaemia

Affiliations

Factors influencing sense of coherence in caregivers of children with acute leukaemia

Chun Yan Liu et al. BMC Nurs. .

Abstract

Background: As an important protective factor for caregivers' well-being, a sense of coherence can reduce a series of negative effects brought about by the care process. Previous studies have focused on the adverse factors that lead to psychological problems in caregivers of children with acute leukaemia. This study explored factors that promote the physical and mental health of caregivers, with a particular focus on the sense of coherence and its influencing factors among caregivers of children with acute leukaemia.

Methods: This study used a cross-sectional design and was completed between February and September 2023. We conducted a questionnaire survey using convenience sampling with 287 children with acute leukaemia and their caregivers who were admitted to a children's hospital in Jiangsu Province. Caregivers completed a general information questionnaire, Sense of Coherence Scale, Social Support Rating Scale, Simplified Coping Style Questionnaire, and General Self-Efficacy Scale. Data were analysed using independent sample t-tests, one-way analysis of variance, Pearson's correlation analysis, and multiple linear regression analysis using the SPSS software.

Results: Univariate analysis identified several influencing factors, including caregivers' gender, relationship with children, education level, current work status, family monthly income per capita, cumulative care time, medical payment method, clinical risk classification, self-care ability, and recurrence. Bivariate analysis showed that sense of coherence was positively correlated with social support, positive coping style, and self-efficacy. Multiple linear regression analysis showed that positive coping style, self-efficacy, family monthly income per capita, caregivers' gender, social support, self-care ability, and the caregiver's relationship with the child contributed to the model, collectively explaining 58.1% of the total variance.

Conclusion: The overall sense of coherence among caregivers of children with acute leukaemia was notably low. According to the identified influencing factors, it is crucial to implement targeted interventions and support caregivers in fully utilising internal and external family resources to promote positive coping strategies and improve their sense of coherence.

Clinical trial number: Not applicable.

Keywords: Acute leukaemia; Caregivers; Cross-sectional; Influencing factors; Paediatric patients; Sense of coherence.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study was approved by the Medical Ethics Committee of Soochow University Children’s Hospital (2023CS027) and written informed consent was obtained from all participants. All the methods followed the principles of the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

References

    1. GBD 2017 Childhood Cancer Collaborators. The global burden of childhood and adolescent cancer in 2017: an analysis of the global burden of disease study 2017. Lancet Oncol. 2019;20(9):1211–25. - PMC - PubMed
    1. Lam CG, Howard SC, Bouffet E, et al. Science and health for all children with cancer. Science. 2019;363(6432):1182–86. - PubMed
    1. Chen SL, Zhang H, Gale RP, et al. Toward the cure of acute lymphoblastic leukemia in children in China. JCO Glob Oncol. 2021;7:1176–86. - PMC - PubMed
    1. Bahoush G, Nojoomi M. Frequency of cytogenetic findings and its effect on the outcome of pediatric acute lymphoblastic leukemia. Med Arch. 2019;73(5):311–5. - PMC - PubMed
    1. Ma MY, Yang QJ, Zhao HH, et al. Research progress in the care load of family caregivers of children with acute leukemia. Med Innov China. 2022;19(24):166–70.

LinkOut - more resources