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. 2025 Aug;212(3):435-436.
doi: 10.1007/s10549-025-07739-x. Epub 2025 May 31.

Severe hyponatremia with abemaciclib use in the absence of pre-existing renal disease

Tae Hoon Kim  1 , Amanda Podolski  2 , Eleonora Teplinsky  2
Affiliations

Severe hyponatremia with abemaciclib use in the absence of pre-existing renal disease

Tae Hoon Kim et al. Breast Cancer Res Treat. 2025 Aug.
No abstract available

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Conflict of interest statement

Declarations. Competing interest: The authors declare no competing interests. Disclosure: The authors have no relevant financial or non-financial interests to disclose. The authors report no conflicts of interest.

References

    1. Sledge J, Toi M, Neven P et al (2017) MONARCH 2: abemaciclib in combination with fulvestrant in women with HR+/HER2- advanced breast cancer who had progressed while receiving endocrine therapy. J Clin Oncol 35(25):2875–2884. https://doi.org/10.1200/JCO.2017.73.7585 - DOI - PubMed
    1. Goetz MP, Martin M, Tokunaga E et al (2020) Health-related quality of life in MONARCH 3: abemaciclib plus an aromatase inhibitor as initial therapy in HR+, HER2− advanced breast cancer. Oncol (Dayton, Ohio) 25(9):e1346–e1354. https://doi.org/10.1634/theoncologist.2020-0084 - DOI
    1. Carleton N, Foldi J (2024) Case report: abemaciclib-induced syndrome of inappropriate antidiuretic hormone (SIADH) without underlying kidney injury in a patient with early-stage estrogen receptor (ER)+ breast cancer. Front Med (Lausanne) 16(10):1338566. https://doi.org/10.3389/fmed.2023.1338566.PMID:38293306;PMCID:PMC10824918 - DOI

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