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. 2025 Jun;603(11):3269-3273.
doi: 10.1113/JP288809. Epub 2025 May 31.

Mechanistic insight into the initiation of spreading depolarizations: Is it really all about potassium?

Rachel Ricks  1 , Connie MacKenzie-Gray Scott  2 , Andrew J Trevelyan  2 , R Ryley Parrish  1   3
Affiliations

Mechanistic insight into the initiation of spreading depolarizations: Is it really all about potassium?

Rachel Ricks et al. J Physiol. 2025 Jun.
No abstract available

Keywords: cell volume; halorhodopsin; spreading depolarization; spreading depression.

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Conflict of interest statement

No competing interests declared.

Figures

Figure 1
Figure 1. Mechanistic convergence of different experimental and natural causes of spreading depolarization
The convergence of various identified causes of spreading depolarization toward a common pathway involving neuronal swelling is illustrated. The secondary increase in extracellular K+ creates a positive feedback loop, which may lead to a regenerate (spreading) event. Blue signifies mechanisms for which there good scientific evidence exists. Orange denotes mechanisms for which there is weaker evidence, and which should be the topic of future research to test this hypothesis further. *The list of possible mediators is not comprehensive.
See this image and copyright information in PMC

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