Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Stephen Gomperts reports financial support was provided by National Institutes of Health. Stephen Gomperts reports a relationship with The Michael J Fox Foundation that includes: funding grants. Stephen Gomperts reports a relationship with Farmer Family Foundation Parkinson's Research Initiative that includes: funding grants. Stephen Gomperts reports a relationship with EIP Pharma that includes: consulting or advisory and funding grants. Stephen Gomperts reports a relationship with Hillhurst Biopharmaceuticals that includes: funding grants. Stephen Gomperts reports a relationship with ACADIA Pharmaceuticals Inc that includes: consulting or advisory. Stephen Gomperts reports a relationship with Janssen Pharmaceuticals Inc that includes: consulting or advisory. Stephen Gomperts reports a relationship with Biogen that includes: consulting or advisory. Stephen Gomperts reports a relationship with Athenium Analytics that includes: consulting or advisory. Stephen Gomperts reports a relationship with Clarivate Analytics US LLC that includes: consulting or advisory. Stephen Gomperts reports a relationship with Guidepoint Global that includes: consulting or advisory. Stephen Gomperts reports a relationship with Cowen Group Inc that includes: consulting or advisory. Stephen Gomperts reports a relationship with US Office of Congressionally Directed Medical Research Programs that includes: funding grants. Stephen Gomperts has patent #PCT/US20/36433 pending to Massachusetts General Hospital. none If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.