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. 2025 Aug:350:116555.
doi: 10.1016/j.psychres.2025.116555. Epub 2025 May 22.

The associations of childhood adversities and mental disorders with suicidal thoughts and behaviors - Results from the World Mental Health International College Student Initiative

Philippe Mortier  1 Xue Yang  2 Yasmin A Altwaijri  3 Jacob A Holdcraft  4 Sue Lee  4 Nancy A Sampson  4 Yesica Albor  5 Ahmad N Alhadi  6 Jordi Alonso  7 Nouf K Al-Saud  3 Claes Andersson  8 Lukoye Atwoli  9 Randy P Auerbach  10 Caroline Ayuya Muaka  11 Patricia M Báez-Mansur  12 Laura Ballester  1 Jason Bantjes  13 Harald Baumeister  14 Marcus Bendtsen  15 Corina Benjet  5 Anne H Berman  16 Ronny Bruffaerts  17 Paula Carrasco  18 Silver C N Chan  19 Irina Cohut  20 María Anabell Covarrubias Díaz Couder  21 Marcelo A Crockett  22 Pim Cuijpers  23 Oana A David  24 Dong Dong  2 David D Ebert  25 Jorge Gaete  26 Mireia Felez-Nobrega  27 Carlos García Forero  28 Margalida Gili  29 Raúl A Gutiérrez-García  30 Josep Maria Haro  31 Penelope Hasking  32 Xanthe Hunt  33 Mathilde M Husky  34 Florence Jaguga  35 Leontien Jansen  36 Álvaro I Langer  37 Yan Liu  38 Scarlett Mac-Ginty  39 Vania Martínez  40 Andre Mason  41 Muthoni Mathai  42 Margaret McLafferty  43 Andrea Miranda-Mendizabal  44 Elaine K Murray  45 Catherine M Musyoka  42 Siobhan M O'Neill  46 Claudiu C Papasteri  47 José A Piqueras  48 Codruta A Popescu  49 Charlene Rapsey  50 Kealagh Robinson  51 Tiscar Rodriguez-Jimenez  52 Damian Scarf  53 Oi-Ling Siu  54 Dan J Stein  55 Sascha Y Struijs  56 Cristina T Tomoiaga  57 Karla Patricia Valdés-García  58 Shelby Vereecke  59 Daniel V Vigo  60 Angel Y Wang  59 Samuel Y S Wong  2 Ronald C Kessler  4 World Mental Health International College Student collaborators
Affiliations

The associations of childhood adversities and mental disorders with suicidal thoughts and behaviors - Results from the World Mental Health International College Student Initiative

Philippe Mortier et al. Psychiatry Res. 2025 Aug.

Abstract

Objective: To investigate the associations of demographic variables, childhood adversities (CAs), and mental disorders (MDx) with onset, transition, and persistence of suicidal thoughts and behaviors (STB) among first-year university students.

Method: Poisson regression models within a discrete-time survival framework were constructed using web-based self-report survey data from 72,288 incoming university students across 18 countries (response rate=20.9%; median age=19 years, 57.9% female, 1.4% transgender, 21.0% non-heterosexual). These models examined the associations of four demographic variables, five CAs, and eight MDx with STB outcomes.

Results: Lifetime prevalence of suicidal ideation, plans, and attempts was 47.0%, 26.0%, and 9.6%, respectively; 12-month estimates were 30.6%, 14.0%, and 2.3%. In unadjusted analyses, associations were strongest between lifetime onset of suicidal ideation and CAs (RR range 4.4-7.0), particularly parental psychopathology (relative risk [RR]=7.0 [95% CI 6.5-7.7]), followed by MDx (RR range 1.3-3.0). Of the demographic subgroups, transgender students had highest risk of STB (lifetime ideation onset RR=2.4 [2.3-2.6]; ideation-to-attempt transition RR=1.5 [1.3-1.8]). In fully adjusted models, strongest predictors of lifetime ideation onset were emotional abuse (RR=2.1 [1.9-2.2]), major depressive disorder (RR=2.0 [1.9-2.1]), and bipolar disorder (RR=1.8 [1.6-2.0]). Ideation-to-attempt transition remained most strongly associated with panic disorder (RR=1.5 [1.3-1.7]), bipolar disorder (RR=1.4 [1.2-1.7]), and sexual abuse (RR=1.4 [1.2-1.7]). Most predictors were significantly but weakly associated with persistence of ideation and plan, while only physical abuse remained associated with repeated suicide attempts (RR=1.3 [1.0-1.8]).

Conclusion: CAs and MDx are strong predictors of both onset of and transition within the STB spectrum, underscoring the importance of implementing early-life prevention interventions.

Keywords: Adverse childhood experiences; Mental health; Prevalence; Risk factors; Self-injurious behavior; Students; Suicide.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Randy P. Auerbach reports financial support was provided by Get Sonar Inc. Randy P. Auerbach reports financial support was provided by RPA Health Consulting, Inc. Randy P. Auerbach reports financial support was provided by Covington & Burling LLP. Ronny Bruffaerts reports financial support was provided by Eli Lilly (IIT-H6U-BX-I002). Xanthe Hunt reports financial support was provided by Sexual Violence Research Institute. Xanthe Hunt reports financial support was provided by Volkswagen Foundation. Xanthe Hunt reports financial support was provided by Wellspring Philanthropies. Xanthe Hunt reports financial support was provided by Foreign. Xanthe Hunt reports financial support was provided by Commonwealth and Development Office (UK government). Xanthe Hunt reports financial support was provided by PANDA Holding Limited. Xanthe Hunt reports financial support was provided by National Research Foundation of South Africa. Xanthe Hunt reports financial support was provided by Center for Inclusive Policy. Xanthe Hunt reports financial support was provided by Mastercard Foundation. Xanthe Hunt reports financial support was provided by Missing Billion Initiative. Xanthe Hunt reports financial support was provided by UNICEF. Xanthe Hunt reports financial support was provided by CGIAR International Food Policy Research Institute. Xanthe Hunt reports financial support was provided by African Union. Xanthe Hunt reports financial support was provided by Charité University Hospital Berlin. David D. Ebert reports financial support was provided by Sanofi. David D. Ebert reports financial support was provided by Novartis. David D. Ebert reports financial support was provided by Minddistrict. David D. Ebert reports financial support was provided by Lantern. David D. Ebert reports financial support was provided by Schoen Kliniken. David D. Ebert reports financial support was provided by Ideamed. David D. Ebert reports financial support was provided by BARMER. David D. Ebert reports financial support was provided by Techniker Krankenkasse. David D. Ebert reports financial support was provided by HelloBetter. Mathilde M. Husky reports financial support was provided by Child Mind Institute Inc. Ronald C. Kessler reports was provided by Cambridge Health Alliance. Ronald C. Kessler reports financial support was provided by Canandaigua VA Medical Center. Ronald C. Kessler reports financial support was provided by Child Mind Institute Inc. Ronald C. Kessler reports financial support was provided by Holmusk. Ronald C. Kessler reports financial support was provided by Massachusetts General Hospital. Ronald C. Kessler reports financial support was provided by Partners Healthcare, Inc. Ronald C. Kessler reports financial support was provided by RallyPoint Networks, Inc. Ronald C. Kessler reports financial support was provided by Sage Therapeutics. Ronald C. Kessler reports financial support was provided by University of North Carolina. Ronald C. Kessler reports financial support was provided by Cerebral Inc. Ronald C. Kessler reports financial support was provided by Mirah. Ronald C. Kessler reports financial support was provided by PYM (Prepare Your Mind). Ronald C. Kessler reports financial support was provided by Roga Sciences. Ronald C. Kessler reports financial support was provided by Verisense Health. Dan J Stein reports financial support was provided by Discovery Vitality. Dan J Stein reports financial support was provided by Johnson & Johnson. Dan J Stein reports financial support was provided by Kanna. Dan J Stein reports financial support was provided by L’Oréal SA. Dan J Stein reports financial support was provided by Lundbeck. Dan J Stein reports financial support was provided by Orion. Dan J Stein reports financial support was provided by Servier. Dan J Stein reports financial support was provided by Seaport Therapeutics. Dan J Stein reports financial support was provided by Takeda. Dan J Stein reports financial support was provided by Vistagen. Dan J Stein reports financial support was provided by Wellcome. Daniel V. Vigo reports financial support was provided by Health Canada. Daniel V. Vigo reports financial support was provided by Provincial Health Services Authority. Daniel V. Vigo reports financial support was provided by Province of BC and Vancouver Coastal Health Authority. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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