Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Nov:165:105822.
doi: 10.1016/j.humpath.2025.105822. Epub 2025 May 30.

Penile cysts: A review of clinicopathological features and differential diagnosis

Roselyne Choiniere  1 , Jeffrey Damman  2 , Geert J L H van Leenders  3
Affiliations
Free article
Review

Penile cysts: A review of clinicopathological features and differential diagnosis

Roselyne Choiniere et al. Hum Pathol. 2025 Nov.
Free article

Abstract

Uncommon and seldom discussed in the literature, the diagnosis of penile cysts relies on morphology and clinical correlation. In this review, we provide a comprehensive overview of the clinicopathological features and differential diagnosis of benign cysts encountered on penile glans, foreskin and shaft. We discuss in more detail the median raphe cyst with its many names and patterns. The aim of this review is to outline the diagnostic considerations and provide practical guidance for pathologists in diagnosing benign penile cysts.

Keywords: Differential diagnosis; Histopathology; Median raphe cyst; Morphology; Penile cyst; Penis; Review.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

LinkOut - more resources