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Review
. 2025 Jun 2;12(1):15.
doi: 10.1186/s44156-025-00078-z.

British Society of Echocardiography guideline for the transthoracic echocardiographic assessment of adult patients with obstructive hypertrophic cardiomyopathy receiving myosin-inhibitor therapy

Clare M Culshaw  1 , Daniel Augustine  2   3 , Caroline J Coats  4 , Ivo Andrade  5 , Keith Pearce  5 , Antonis Pantazis  6 , William Bradlow  7 , Lauren Turvey  7 , William Moody  8 , Lynne Williams  9 , Rachel Bastianen  10 , Jane Draper  10 , David L Oxborough  11 , Robert M Cooper  12   13
Affiliations
Review

British Society of Echocardiography guideline for the transthoracic echocardiographic assessment of adult patients with obstructive hypertrophic cardiomyopathy receiving myosin-inhibitor therapy

Clare M Culshaw et al. Echo Res Pract. .
No abstract available

Keywords: Mavacamten; Myosin-inhibitor; Obstructive HCM; Surveillance Echocardiogram.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Recommended algorithm for patients who are normal and rapid CYP metabolisers. *Interrupt treatment at any point if LVEF <50%
Fig. 2
Fig. 2
Recommended algorithm for patients who are slow/poor CYP metabolisers or while CYP status is pending. *Interrupt treatment at any point if LVEF <50%
Fig. 3
Fig. 3
Maintenance assessment algorithm. Echocardiography should be performed every 24 weeks unless a dose titration is needed or LVEF drops to < 50%
Fig. 4
Fig. 4
Actions if LVEF drops to < 50%. If at any visit the patient’s LVEF is < 50%, the treatment should be interrupted for at least 4 weeks and only restarted if LVEF ≥ 50%
See this image and copyright information in PMC

References

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