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. 2025 Jun 1;25(2):252-255.
doi: 10.22540/JMNI-25-252.

Regional Migratory Osteoporosis

Affiliations

Regional Migratory Osteoporosis

Christos Koutserimpas et al. J Musculoskelet Neuronal Interact. .
No abstract available

Keywords: 25-OH-D3; Bisphosphonates; Hip; Knee; Transient Osteoporosis.

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Conflict of interest statement

The authors have no conflict of interest.

Figures

Figure 1
Figure 1
(A) Axial and (B) coronal T2-weighted fat-saturated magnetic resonance (MR) images of the hips demonstrate diffuse heterogeneous signal hyperintensity affecting the bone marrow of the right femoral head, neck, and part of the intertrochanteric region (thick arrows), indicating bone marrow edema. A mild joint effusion is also noted (thin arrows). (C) Coronal T1-weighted MR image of the hips displays areas with partial loss of the normal fatty marrow signal in corresponding bone marrow edema areas of the right hip (thick arrow), which is most evident when compared to the contralateral normal side. (D) Axial and (E) coronal T2-weighted fat-saturated magnetic resonance (MR) images of the hips from a different MR examination demonstrate diffuse heterogeneous signal hyperintensity affecting the bone marrow of the left femoral head, neck, and part of the intertrochanteric region (thick arrows), suggestive of bone marrow edema. A mild joint effusion is also noted (thin arrows). (F) Coronal T1-weighted MR image of the hips displays areas with partial loss of the normal fatty marrow signal in corresponding bone marrow edema areas of the left hip (thick arrow), likewise most evident when compared to the contralateral normal side. These findings are identical to those described for the right hip. Note that in both hips, the medial part of the femoral head is spared (asterisk), an imaging finding characteristic of transient osteoporosis of the hip (otherwise known as transient bone marrow edema syndrome of the hip).
Figure 2
Figure 2
(A) Coronal and (B) axial proton density (PD) fat-saturated magnetic resonance (MR) images of the right knee demonstrate diffuse heterogeneous signal hyperintensity affecting the bone marrow of both femoral condyles (arrows), indicating bone marrow edema. (C) Coronal T1-weighted MR image of the right knee only displays mild areas with partial loss of the normal fatty marrow signal in the corresponding regions. (D) Sagittal T2-weighted, non-fat-saturated image at the level of the medial part of the lateral femoral condyle barely visualizes a thin subchondral fracture line of low signal intensity (arrow).

References

    1. Komnos GA, Paridis DI, Banios KT, Karachalios TS, Dailiana ZH, Luceri F, Randelli PS. Regional migratory osteoporosis of the knee:a literature overview. Musculoskelet Surg. 2023;107:159–164. - PubMed
    1. Grøvle L, Haugen AJ, Johansen M, Hasvik E. The terminologies of transient, migratory, or localized osteoporosis, and bone marrow edema syndrome:a scoping review. Osteoporos Int. 2024;35:217–226. - PMC - PubMed
    1. Klontzas ME, Vassalou EE, Zibis AH, Bintoudi AS, Karantanas AH. MR imaging of transient osteoporosis of the hip:an update on 155 hip joints. Eur J Radiol. 2015;84:431–436. - PubMed
    1. Evangelatos G, Fragoulis GE, Zampeli E, Kechagia M, Iliopoulos A. Zoledronic acid is effective and safe in migratory osteoporosis. Rheumatology (Oxford) 2020;59:439–440. - PubMed
    1. Evangelatos G, Fragoulis GE, Iliopoulos A. Zoledronic acid in nine patients with transient osteoporosis of the hip. Clin Rheumatol. 2020;39:291–293. - PubMed