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Randomized Controlled Trial
. 2025 Jun;38(3):e70071.
doi: 10.1111/jhn.70071.

Cost-Effectiveness of Personalised Nutrition in Adults With Overweight and Obesity: PREVENTOMICS Studies in Poland and the UK

Milanne Maria Johanna Galekop  1 , Philip C Calder  2   3 , Ella J Baker  2   3 , Joanna Góralska  4 , Urszula Raźny  4 , Malgorzata Malczewska-Malec  4 , Carin A Uyl-de Groot  1 , William Ken Redekop  1
Affiliations
Randomized Controlled Trial

Cost-Effectiveness of Personalised Nutrition in Adults With Overweight and Obesity: PREVENTOMICS Studies in Poland and the UK

Milanne Maria Johanna Galekop et al. J Hum Nutr Diet. 2025 Jun.

Abstract

Background: We assessed the cost-effectiveness of personalised nutrition in adults with overweight/obesity in Poland and the United Kingdom (UK) using the results of two randomised controlled trials (RCTs).

Methods: The 4-month RCTs compared three interventions: personalised plan (PP) plus behavioural change (PP+B), PP only, and a control. Outcomes included body mass index (BMI), health-related quality of life (EQ-5D-5L), quality-adjusted life years (QALYs), and costs (2020 British pounds). A Markov model estimated lifetime cost-effectiveness. Different sensitivity analyses were performed.

Results: Participants were randomised to PP+B, PP, and control groups in Poland (n = 89, n = 88, n = 88) and the UK (n = 20, n = 19, n = 15). Comparing BMI reductions of PP+B and PP with control in both countries showed no significant differences, but wide confidence intervals (CIs) were observed (e.g., PP+B vs. control-Poland: -0.20, 95% CI: -0.86, 0.45 kg/m2; UK: -0.80, 95% CI: -1.60, 0.00 kg/m2). Lifetime analysis suggested potential cost-effectiveness for PP+B in Poland (£20,404 per QALY gain), and for PP+B (£13,006 per QALY) and PP (£12,222 per QALY) in the UK, since these figures were lower than the willingness-to-pay thresholds (£34,000 in Poland and £20,000 in the UK). PP in Poland was dominated by control, but sensitivity analyses suggested potential cost-effectiveness.

Conclusions: The PREVENTOMICS interventions may offer a cost-effective approach to reduce weight and avoid its related complications in both countries. Future studies should be larger and/or longer to reduce uncertainty about effectiveness.

Clinical trial registration numbers: Poland ISRCTN51509551 and the UK ISRCTN46063864.

Keywords: cost‐effectiveness analysis; obesity; overweight; personalised nutrition.

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Conflict of interest statement

At the time of submission, Milanne M.J. Galekop was an employee at GlaxoSmithKline BV (GSK), but GSK was not involved in this study in any way nor did this author contribute to this study in the capacity of her role within GSK. The other authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Structure of the Markov model for obesity as described by Hoogendoorn et al. [5] BMI, body mass index; IHD, ischemic heart disease.
Figure 2
Figure 2
Tornado diagrams for change in ICURs using lower and upper bounds of parameters (A) for Poland in the PP+B group (in PLN per QALY), (B) for Poland in the PP group (in PLN per QALY), (C) for the UK in the PP+B group (in £ per QALY), and (D) for the UK in the PP group (in £ per QALY). BMI, body mass index; IHD, ischemic heart disease; QoL, quality of life. *No fixed number, since costs differ by sex and age.
Figure 3
Figure 3
Cost‐effectiveness plane resulted from the probabilistic sensitivity analysis in (A) Poland: PP+B versus control, (B) Poland: PP versus control, (C) UK: PP+B versus control, and (D) UK: PP versus control. PLN, Zloty; QALYs, quality‐adjusted life years; WTP, willingness‐to‐pay.
See this image and copyright information in PMC

References

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