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Case Reports
. 2025 May 30;12(6):e01716.
doi: 10.14309/crj.0000000000001716. eCollection 2025 Jun.

Treatment of Autoimmune Enteropathy With Vedolizumab

Tara Alleyasin  1 , Evan Wilder  2 , Warren Reidel  2 , Emma Du  3 , Quan M Nhu  1   2   4
Affiliations
Case Reports

Treatment of Autoimmune Enteropathy With Vedolizumab

Tara Alleyasin et al. ACG Case Rep J. .

Abstract

Autoimmune enteropathy (AIE) is a rare condition characterized by immune-mediated villous atrophy with associated chronic diarrhea. In this case, a 34-year-old man with AIE was treated with vedolizumab, an anti-ɑ4b7 integrin that inhibits intestinal lymphocyte trafficking, after initial treatments with prednisone, open-capsule budesonide, azathioprine, infliximab, and adalimumab showed minimal response. Vedolizumab resulted in moderate symptomatic and histological improvement but was discontinued due to possible drug-induced liver injury. This case suggests the potential therapeutic efficacy of vedolizumab in treating AIE, though more research is needed.

Keywords: autoimmune enteropathy; vedolizumab.

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Figures

Figure 1.
Figure 1.
(A) (100×) Duodenal biopsies showed villous atrophy, increased intraepithelial lymphocytes, and loss of goblet and Paneth cells. (B) (200×) Histological improvement on vedolizumab.
See this image and copyright information in PMC

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