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. 2025 May 16:16:1563108.
doi: 10.3389/fimmu.2025.1563108. eCollection 2025.

Emerging research themes in ferroptosis research for non-small cell lung cancer: a bibliometric and visualized analysis

Wenbo Zhang  1   2   3   4 , Jianwei Gu  1   2   3   4 , Yong Chen  2 , Guolu Jiang  2 , Diego Gonzalez-Rivas  3   5 , Minjie Ma #  3 , Chang Chen #  1   4   6
Affiliations

Emerging research themes in ferroptosis research for non-small cell lung cancer: a bibliometric and visualized analysis

Wenbo Zhang et al. Front Immunol. .

Abstract

Background: Ferroptosis, an iron-dependent form of regulated cell death, has garnered significant attention as a potential therapeutic target in oncology due to its unique mechanism involving lipid peroxidation and reactive oxygen species accumulation. In non-small cell lung cancer (NSCLC), ferroptosis offers promising strategies to overcome drug resistance and enhance the efficacy of existing therapies. While the literature on ferroptosis in NSCLC has expanded rapidly over the past decade, a comprehensive understanding of its research trends, global collaboration patterns, and emerging hotspots remains lacking.

Objective: This study employs bibliometric and visualized analysis to systematically evaluate global research trends, influential contributors, and thematic evolution in ferroptosis research for NSCLC. The findings aim to guide future investigations and promote interdisciplinary collaborations.

Methods: Data were extracted from the Web of Science Core Collection on December 24, 2024. Bibliometric tools including VOSviewer, CiteSpace, and GraphPad Prism were used to analyze publication trends, citation patterns, collaborative networks, and research hotspots. Key indicators such as publication output, geographic contributions, institutional performance, and keyword co-occurrence were visualized to elucidate the field's development.

Results: A total of 964 publications from 52 countries and regions were analyzed, with China and the United States emerging as the most influential contributors. Chinese institutions such as Fudan University and Central South University led in publication output, while US-based authors had the highest citation impact. Research hotspots included ferroptosis mechanisms, biomarkers, oxidative stress, immunotherapy, and drug resistance. Keyword and citation analyses reveal an increasing emphasis on integrating ferroptosis inducers with immune checkpoint inhibitors and leveraging nanomedicine for targeted therapy.

Conclusion: This bibliometric analysis highlights the rapid expansion of ferroptosis research in NSCLC, revealing key contributors, global trends, and emerging areas of focus. The integration of ferroptosis with immunotherapy and precision medicine holds immense promise for advancing NSCLC treatment. Future research should prioritize international collaboration, explore resistance mechanisms, and harness advanced technologies such as nanomedicine and artificial intelligence to maximize therapeutic potential.

Keywords: bibliometrics; biomarkers; drug resistance; ferroptosis; immunotherapy; nanomedicine; non-small cell lung cancer.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of literature search.
Figure 2
Figure 2
Published trend chart concerning ferroptosis research for non-small cell lung cancer.
Figure 3
Figure 3
Country/region collaboration network of research on ferroptosis for non-small cell lung cancer. (A) Line graph of national publications. (B) Heat map of national publications. (C) Networks of country cooperation, node size represents the volume of publications and the line color represents the year of collaboration.
Figure 4
Figure 4
Networks of institutional co-operation.
Figure 5
Figure 5
Analysis of journal sources. (A) Density web map of journal publications. (B) Co-citation network map of journals. (C) Dual map of journals.
Figure 6
Figure 6
Cooperation network of authors.
Figure 7
Figure 7
Co-citation network of authors.
Figure 8
Figure 8
Analysis cited references and co-cited references. (A) Co-cited network of literature. (B) Clustering of co-cited literature. (C) Peak map of co-cited literature. (D) Bursting map of cited literature.
Figure 9
Figure 9
Analysis of keywords associated with ferroptosis in non-small cell lung cancer. (A) Network map of high-frequency keywords. (B) Density map of keywords. (C) Peak map of keyword clustering. (D) Clustering map of keywords.
Figure 10
Figure 10
Bursting map of keywords.
See this image and copyright information in PMC

References

    1. Liu X, Zhang Y, Wu X, Xu F, Ma H, Wu M, et al. . Targeting ferroptosis pathway to combat therapy resistance and metastasis of cancer. Front Pharmacol. (2022) 13:909821. doi: 10.3389/fphar.2022.909821 - DOI - PMC - PubMed
    1. Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. . Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. (2012) 149:1060–72. doi: 10.1016/j.cell.2012.03.042 - DOI - PMC - PubMed
    1. Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AL, Conrad M, Dixon SJ, et al. . Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease. Cell. (2017) 171:273–85. doi: 10.1016/j.cell.2017.09.021 - DOI - PMC - PubMed
    1. Qi R, Bai Y, Li K, Liu N, Xu Y, Dal E, et al. . Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4-targeting miRNAs. Drug resistance updates. (2023) 68:100960. doi: 10.1016/j.drup.2023.100960 - DOI - PubMed
    1. Zhang C, Liu X, Jin S, Chen Y, Guo R. Ferroptosis in cancer therapy: a novel approach to reversing drug resistance. Mol Cancer. (2022) 21:47. doi: 10.1186/s12943-022-01530-y - DOI - PMC - PubMed

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