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Review
. 2025 Jun 2;82(7):319.
doi: 10.1007/s00284-025-04260-8.

Investigating c-di-GMP Signaling in Vibrio parahaemolyticus: Biological Effects and Mechanisms of Regulation

Pu Yao  1 , Yiquan Zhang  2 , Jun Ding  3
Affiliations
Review

Investigating c-di-GMP Signaling in Vibrio parahaemolyticus: Biological Effects and Mechanisms of Regulation

Pu Yao et al. Curr Microbiol. .

Abstract

Vibrio parahaemolyticus is a halophilic, Gram-negative bacterium found in marine and estuarine ecosystems and is a significant contributor to seafood-related bacterial gastroenteritis. Cyclic di-GMP (c-di-GMP) is a widespread secondary messenger that modulates various cellular pathways, including virulence factor production, motility, and biofilm formation. c-di-GMP is made by diguanylate cyclases (DGCs), while its breakdown is mediated by phosphodiesterases (PDEs). Although many putative DGCs and PDEs involved in c-di-GMP metabolism have been identified in V. parahaemolyticus, only a few have been thoroughly studied. Furthermore, the metabolism of c-di-GMP is influenced by various environmental factors and transcriptional regulators. This review provides an overview of the c-di-GMP signaling network in V. parahaemolyticus, focusing on recent advancements related to c-di-GMP metabolic enzyme genes and their regulatory mechanisms. Understanding the intricate mechanisms of c-di-GMP metabolism and regulation is crucial for revealing the environmental adaptation and pathogenic strategies of V. parahaemolyticus.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no conflict of interest.

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References

    1. Huang Q, Zhang Y, Zhang M, Li X, Wang Q, Ji X, Chen R, Luo X, Ji S, Lu R (2024) Assessment of Vibrionaceae prevalence in seafood from Qidong market and analysis of Vibrio parahaemolyticus strains. PLoS ONE 19(8):e0309304. https://doi.org/10.1371/journal.pone.0309304 - DOI - PubMed - PMC
    1. Yang C, Li Y, Jiang M, Wang L, Jiang Y, Hu L, Shi X, He L, Cai R, Wu S, Qiu Y, Lu L, Zuo L, Chen Q, Wu Y, Martinez-Urtaza J, Wan C, Yang R, Cui Y, Hu Q (2022) Outbreak dynamics of foodborne pathogen Vibrio parahaemolyticus over a seventeen year period implies hidden reservoirs. Nat Microbiol 7(8):1221–1229. https://doi.org/10.1038/s41564-022-01182-0 - DOI - PubMed
    1. Broberg CA, Calder TJ, Orth K (2011) Vibrio parahaemolyticus cell biology and pathogenicity determinants. Microbes Infect 13(12–13):992–1001. https://doi.org/10.1016/j.micinf.2011.06.013 - DOI - PubMed - PMC
    1. Li L, Meng H, Gu D, Li Y, Jia M (2019) Molecular mechanisms of Vibrio parahaemolyticus pathogenesis. Microbiol Res 222:43–51. https://doi.org/10.1016/j.micres.2019.03.003 - DOI - PubMed
    1. Matsuda S, Okada R, Tandhavanant S, Hiyoshi H, Gotoh K, Iida T, Kodama T (2019) Export of a Vibrio parahaemolyticus toxin by the Sec and type III secretion machineries in tandem. Nat Microbiol 4(5):781–788. https://doi.org/10.1038/s41564-019-0368-y - DOI - PubMed

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