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. 2025 Jul 1;82(7):749-751.
doi: 10.1001/jamaneurol.2025.1433.

Antithrombotic Therapy After Burr Hole Evacuation of Chronic Subdural Hematoma: A Post Hoc Analysis of 2 Randomized Clinical Trials

Anders Schack  1   2   3 , Frantz Rom Poulsen  1   3 , Birgit Debrabant  2 , Thorbjørn Søren Rønn Jensen  4 , Rares Miscov  5 , Mette Haldrup  6 , Lejla Islamagic  6 , Ann Kathrine Sindby  6 , Kåre Fugleholm  2 , Bo Bergholt  6 , Carsten Reidies Bjarkam  5 , Anders Rosendal Korshøj  6   7 , Mads Hjortdal Grønhøj  1   3
Affiliations

Antithrombotic Therapy After Burr Hole Evacuation of Chronic Subdural Hematoma: A Post Hoc Analysis of 2 Randomized Clinical Trials

Anders Schack et al. JAMA Neurol. .
No abstract available

Plain language summary

This study investigates outcomes in patients undergoing surgery for chronic subdural hematoma comparing those receiving vs not receiving antithrombotic therapy.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Korshøj reported serving on advisory boards for Novocure and receiving grants from Novocure and IRRAS for investigator-initiated trials unrelated to this study. No other disclosures were reported.

References

    1. Wang Y, Zhou J, Fan C, et al. Influence of antithrombotic agents on the recurrence of chronic subdural hematomas and the quest about the recommencement of antithrombotic agents: a meta-analysis. J Clin Neurosci. 2017;38:79-83. doi: 10.1016/j.jocn.2016.12.001 - DOI - PubMed
    1. Fornebo I, Sjåvik K, Alibeck M, et al. Role of antithrombotic therapy in the risk of hematoma recurrence and thromboembolism after chronic subdural hematoma evacuation: a population-based consecutive cohort study. Acta Neurochir (Wien). 2017;159(11):2045-2052. doi: 10.1007/s00701-017-3330-x - DOI - PMC - PubMed
    1. Zhang JJ, Aw NM, Tan CH, et al. Impact of time to resumption of antithrombotic therapy on outcomes after surgical evacuation of chronic subdural hematoma: a multicenter cohort study. J Clin Neurosci. 2021;89:389-396. doi: 10.1016/j.jocn.2021.05.036 - DOI - PubMed
    1. Jensen TS, Haldrup M, Hjortdal Grønhøj M, et al. National randomized clinical trial on subdural drainage time after chronic subdural hematoma evacuation. J Neurosurg. 2021;137(3):799-806. doi: 10.3171/2021.10.JNS211608 - DOI - PubMed
    1. Hjortdal Grønhøj M, Jensen TS, Miscov R, et al. ; DACSUHS Group . Optimal drainage time after evacuation of chronic subdural haematoma (DRAIN TIME 2): a multicentre, randomised, multiarm and multistage non-inferiority trial in Denmark. Lancet Neurol. 2024;23(8):787-796. doi: 10.1016/S1474-4422(24)00175-3 - DOI - PubMed

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