Blood-Based Colorectal Cancer Screening: The Illusion of Simplicity and the Cancer Prevention Paradox

Jason A Dominitz^{1

2}, Swati G Patel^{3

4}, David A Lieberman⁵

Affiliations

¹ National Gastroenterology and Hepatology Program, Veterans Health Administration, Washington, DC.
² Division of Gastroenterology, Department of Medicine, University of Washington School of Medicine, Seattle.
³ Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colorado.
⁴ Division of Gastroenterology, Department of Medicine, University of Colorado School of Medicine, Aurora.
⁵ Division of Gastroenterology, Department of Medicine, Oregon Health and Science University, Portland.

Comment

Jason A Dominitz et al. JAMA. 2025.

. 2025 Jul 1;334(1):29-31.

doi: 10.1001/jama.2025.7557.

Jason A Dominitz^{1

2}, Swati G Patel^{3

4}, David A Lieberman⁵

¹ National Gastroenterology and Hepatology Program, Veterans Health Administration, Washington, DC.
² Division of Gastroenterology, Department of Medicine, University of Washington School of Medicine, Seattle.
³ Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colorado.
⁴ Division of Gastroenterology, Department of Medicine, University of Colorado School of Medicine, Aurora.
⁵ Division of Gastroenterology, Department of Medicine, Oregon Health and Science University, Portland.

No abstract available

Comment on

Clinical Validation of a Circulating Tumor DNA-Based Blood Test to Screen for Colorectal Cancer.
Shaukat A, Burke CA, Chan AT, Grady WM, Gupta S, Katona BW, Ladabaum U, Liang PS, Liu JJ, Putcha G, Robertson DJ, Schoen RE, Meng Z, Piscitello A, Sun CK, Xu C, Lin CJ, Lee LC, Baldo L, Levin TR; PREEMPT CRC Investigators. Shaukat A, et al. JAMA. 2025 Jul 1;334(1):56-63. doi: 10.1001/jama.2025.7515. JAMA. 2025. PMID: 40455622