doi: 10.1002/path.1711470102.
Functional and morphological changes in post-capillary venules in relation to lymphocytic infiltration into BCG-induced granulomata in rat skin
- PMID: 4045596
- DOI: 10.1002/path.1711470102
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Functional and morphological changes in post-capillary venules in relation to lymphocytic infiltration into BCG-induced granulomata in rat skin
J Pathol.
1985 Sep.
Abstract
Vessels identical to lymph node high endothelial venules (HEV) have been described in sites of non-lymphoid tissue lymphocyte accumulation. In this study the function of these (HEV-like) vessels has been investigated in BCG-induced skin lesions in the rat. By following the traffic of radiolabelled lymphocytes from the blood into the lesions the HEV-like vessels have been shown to be the preferred site of migration. The complicated development of the vessels has been studied and an hypothesis advanced to explain their inter-relationship with tissue and circulating lymphocytes.
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