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Review
. 2025 Sep 15:1863:149739.
doi: 10.1016/j.brainres.2025.149739. Epub 2025 May 31.

ACE2/Angiotensin-(1-7)/Mas and the brain

Maria José Campagnole-Santos  1 , Marco Antônio Peliky Fontes  1 , Thiago Verano-Braga  1 , Andrea Siqueira Haibara  1 , Michael Bader  2 , Robson A S Santos  3
Affiliations
Review

ACE2/Angiotensin-(1-7)/Mas and the brain

Maria José Campagnole-Santos et al. Brain Res. .

Abstract

It is well known that the renin-angiotensin system (RAS) plays a key role in regulating blood pressure and hydroelectrolyte balance. In addition to angiotensin (Ang) II, Ang-(1-7) has emerged as an important component of this system. Here we review evidence regarding the presence and actions of ACE2/Ang-(1-7)/Mas receptor pathway within the central nervous system, where the RAS possesses a crucial role in controlling cardiovascular, metabolic and stress-coping behavior functions. The involvement of this non-canonical RAS pathway in the brain mechanisms related to hypertension will also be discussed.

Keywords: Angiotensin; Autonomic regulation; Baroreflex; Chemoreflex; Stress and anxiety; Stroke.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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