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. 2025 Jun 3;34(2):90-96.
doi: 10.4274/mirt.galenos.2025.93797.

The Effect of GLUT-1-XbaI G>T and HaeIII T>C Polymorphisms on 18F-FDG Uptake Rates

Melih Kısaarslan  1 , Yasemin Adalı  1 , Veli Kaan Aydın  1 , Yasemin Berberoğlu  1 , Doğangün Yüksel  2 , Aylin Köseler  1
Affiliations

The Effect of GLUT-1-XbaI G>T and HaeIII T>C Polymorphisms on 18F-FDG Uptake Rates

Melih Kısaarslan et al. Mol Imaging Radionucl Ther. .

Abstract
in English, Turkish

Objectives: To investigate the effects of glut polymorphisms on 18Fluorine-fluorodeoxyglucose (18F-FDG) uptake rates.

Methods: The 18F-FDG positron emission tomography/computed tomography images and mass lesion metabolism standard uptake value maximum (SUVmax) results of the patients were evaluated. Glucose transporter protein-1 (GLUT-1)-XbaI G>T (rs2754218) and HaeIII T>C (rs1385129) polymorphisms and their effects on 18F-FDG uptake rates were investigated using DNA obtained from peripheral blood.

Results: When the Xbal G>T genotype distribution of the patients was examined, the Xbal G/G genotype was found to be 87%, the Xbal G/T genotype 12%. The XbaI T/T phenotype was detected in only one patient (1%). In the HaeIII T>C genotype distribution, the HaeIII C/C genotype was found as 54%, the HaeIII T/C genotype as 31%, and the HaeIII T/T genotype as 15%. When the Xbal and HaeIII genotypes were examined together, the number of polymorphic genotypes was significantly higher in the lung and bronchial tumor groups compared to other cancer types.

Conclusion: The presence of polymorphism in at least one of the two gene regions, in the lung-bronchial tumor group and the high SUVmax value in this patient group, may indicate a change in the involvement rates.

Amaç: Glut polimorfizmlerinin 18Flor-florodeoksiglukoz (18F-FDG) alım oranları üzerindeki etkisinin araştırılmasıdır.

Yöntem: Hastaların pozitron emisyon tomografisi/bilgisayarlı tomografi görüntüleri ve kitle lezyon metabolizması standart alım değeri maksimum (SUVmaks) sonuçları değerlendirildi. Periferik kandan alınan DNA ile hastalarda glikoz taşıyıcı protein-1 (GLUT-1)-XbaI G>T (rs2754218) ve HaeIII T>C (rs1385129) polimorfizmleri ve 18F-FDG tutulum oranlarına etkileri araştırıldı.

Bulgular: Hastaların Xbal G>T genotip dağılımına bakıldığında, Xbal G/G genotipi %87; Xbal G/T genotipi %12 olarak bulundu. Xbal T/T fenotipi sadece 1 hastada (%1) tespit edildi. HaeIII T>C genotip dağılımında, HaeIII C/C genotipi %54; HaeIII T/C genotipi %31; HaeIII T/T genotipi %15 olarak bulundu. Xbal ve HaeIII genotipleri birlikte incelendiğinde, polimorfik genotip sayısının akciğer ve bronşiyal tümör gruplarında diğer kanser tiplerine göre anlamlı derecede yüksek olduğu görülmüştür.

Sonuç: Akciğer-bronşiyal tümör grubunda hastalardaki iki gen bölgesinden en az birinde polimorfizmin olması ve bu hasta grubunda SUVmaks değerinin yüksek olması tutulum oranlarında bir değişikliğe işaret edebilir.

Keywords: 18Fluorine-fluorodeoxyglucose; Glucose transporter protein-1 polymorphism; HaeIII T>C (rs1385129); glucose transporter protein-1-XbaI G>T (rs2754218); positron emission tomography imaging.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1
K indicates that the G>T nucleotide change in the sequence analysis is inherited in heterozygous form
Figure 2
Figure 2
Y indicates that the C>T nucleotide change in the sequence analysis was inherited in a heterozygous form
Figure 3
Figure 3
PET/CT images of patients with lung-bronchial cancer PET/CT images of a 70-year-old male showing the left lung. SUVmax: 7.56. (Xbal G>T genotype: G/G; HaeIII T>C genotype: C/C) B: PET/CT images of a 53-year-old male on the right lung. SUVmax: 10.37. (Xbal G>T genotype: G/T; HaeIII T>C genotype: T/C) PET/CT: Positron emission tomography/computed tomography, SUVmax: Maximum standardized uptake value
See this image and copyright information in PMC

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