Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jun 17;19(23):21571-21588.
doi: 10.1021/acsnano.5c03744. Epub 2025 Jun 3.

Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing

Affiliations

Astragalus Polysaccharide Hydrogels with Drug-Carrying Super Self-Assembly from Natural Herbs Promote Wound Healing

Mingyuan Zhao et al. ACS Nano. .

Abstract

The regulation of the immune microenvironment is a key component of wound healing, where suitable wound dressings with skin immunoreactivity can favorably affect the immune process and promote the repairing progress. Therefore, we developed an injectable photo-cross-linkable composite hydrogel─oxidized astragalus polysaccharide and carboxymethyl chitosan/sodium methacrylated alginate and magnesium ions hydrogel (OAPS-CMC/SAMA-Mg2+, OCS) loaded with curcumin (Cur)-encapsulated Achyranthes bidentata supramolecular self-assemblies (NX SSA) (NX@Cur)─termed OCS/NX@Cur to synergistically accelerate skin repair. The astragalus polysaccharide-dominated hydrogel matrix provided a superior anti-inflammatory ability. Meanwhile, NX@Cur provided strong angiogenesis and accelerated collagen deposition. In cellular experiments and a rat model of total skin defects, the OCS/NX@Cur exhibited superior anti-inflammatory, antioxidant, and angiogenic capabilities. These properties modulated the inflammatory environment of the wound, thereby promoting the formation of granulation tissue and neovascularization and accelerating collagen deposition and re-epithelialization. In conclusion, OCS/NX@Cur showed excellent wound repair capabilities, providing a potential therapeutic option for the combination of super self-assembly and natural polysaccharide hydrogels for wound repair.

Keywords: angiogenesis; anti-inflammatory; astragalus polysaccharides; injectable hydrogel; self-assembly; wound repair.

PubMed Disclaimer

MeSH terms

LinkOut - more resources