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. 2025 May 30;59(2):1-8.
doi: 10.2478/raon-2025-0029. eCollection 2025 Jun 1.

MRI features and prognostic evaluation in patients with subventricular zone-contacting IDH-wild-type glioblastoma

Shijiao Pan  1 , Yang Chen  1 , Shan Zhao  1 , Jingjing Pan  2 , Shengsheng Xu  1
Affiliations

MRI features and prognostic evaluation in patients with subventricular zone-contacting IDH-wild-type glioblastoma

Shijiao Pan et al. Radiol Oncol. .

Abstract

Background: The subventricular zone (SVZ), the brain's largest neural stem cells reservoir, plays a critical role in glioblastoma development and progression. This study aims to investigate the association between MRI features and SVZ contact in IDH-wild-type glioblastoma, as well as their prognostic significance to guide personalized diagnosis and treatment.

Patients and methods: We retrospectively analyzed the MRI and clinical data of 371 patients with IDH-wild-type glioblastoma from The Cancer Imaging Archive. Tumors were classified into SVZ contact and non-contact group based on the spatial relationships between contrast-enhanced lesions and the SVZ on T1C imaging. Group differences were analyzed, and survival outcomes were assessed using Cox regression and Kaplan-Meier analyses.

Results: SVZ contact was observed in 64.4% of patients, these patients exhibited significantly shorter overall survival (OS) compared to the SVZ non-contact group (11.0 vs. 17.5 months, p < 0.001), larger tumor size (5.07 vs. 3.31 cm, p < 0.001), and higher rates of crossing the midline (11.7% vs. 0%, p < 0.001). They also showed higher rates of cystic lesions and necrosis. Cox regression confirmed SVZ contact as an independent predictor of poor OS (p = 0.027), alongside multifocal lesions and age. OS significantly differed by SVZ contact regions (p < 0.001), with temporal horn contact linked to longer OS and body contact to shorter OS.

Conclusions: SVZ contact is an independent prognostic factor for OS in IDH-wild-type glioblastoma, they exhibit larger tumor size, higher rates of crossing the midline, and multifocality. Prognostic differences among SVZ contact regions warrant further investigation to explore the role of their distinct microenvironments.

Keywords: MRI feature; glioblastoma; overall survival; prognosis; subventricular zone.

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Figures

Figure 1.
Figure 1.
The anatomical relationship between glioblastoma and the subventricular zone (SVZ). (A) Contrast-enhancing tumor lesions that do not contact the SVZ are classified as the SVZ non-contact group. (B) Contrastenhancing tumor lesions that contact the SVZ are classified as the SVZ contact group.
FIGURE 2.
FIGURE 2.
Glioblastomas with SVZ contact are further divided into four groups according to the specific regions of the lateral ventricle contacted. (A) Tumor contacting the frontal horn of the left lateral ventricle. (B) Tumor contacting the body of the left lateral ventricle. (C) Tumor contacting the temporal horn of the right lateral ventricle. (D) Tumor contacting the occipital horn of the right lateral ventricle.
Figure 3.
Figure 3.
Axial (A) and coronal (B) contrast-enhanced T1-weighted MR images of a GBM patient with multifocal manifestations. Panels (C) and (D) illustrate another GBM patient with a tumor crossing the midline, where the contrast-enhanced lesion extends from the corpus callosum to the contralateral hemisphere.
FIGURE 4.
FIGURE 4.
Kaplan-Meier curves for overall survival in glioblastoma: (A) Patients with and without SVZ contact; (B) Patients with tumors contacting specific SVZ regions. SVZ =subventricular zone
See this image and copyright information in PMC

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