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. 2025 Jun 2.
doi: 10.1515/dx-2025-0068. Online ahead of print.

Clinical implications of conjugated vs. direct bilirubin testing: analytical limits and clinical consequences

Oswald Sonntag  1 , Giuseppe Lippi  2
Affiliations

Clinical implications of conjugated vs. direct bilirubin testing: analytical limits and clinical consequences

Oswald Sonntag et al. Diagnosis (Berl). .
No abstract available

Keywords: bilirubin; clinical implications; direct and conjugated.

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References

    1. Lo, DH, Wu, TW. Assessment of the fundamental accuracy of the Jendrassik-Grof total and direct bilirubin assays. Clin Chem 1983;29:31–6. https://doi.org/10.1093/clinchem/29.1.31 . - DOI
    1. Doumas, BT, Wu, TW, TW. The measurement of bilirubin fractions in serum. Crit Rev Clin Lab Sci 1991;28:415–45. https://doi.org/10.3109/10408369109106872 . - DOI - PubMed
    1. Guerra Ruiz, AR, Crespo, J, López Martínez, RM, Iruzubieta, P, Casals Mercadal, G, Lalana Garcés, M, et al.. Measurement and clinical usefulness of bilirubin in liver disease. Review. Adv Lab Med 2021;2:352–61. https://doi.org/10.1515/almed-2021-0047 . - DOI - PubMed - PMC
    1. Ou, CN, Buffone, GJ, Herr Calomeni, PJ, Finegold, MJ, Shirey, TL. Conjugated bilirubin versus direct bilirubin in neonates. Am J Clin Pathol 1986;85:613–6. https://doi.org/10.1093/ajcp/85.5.613 . - DOI - PubMed
    1. Thurlow, V, Bailey, IR, Griffiths, W. Conjugated bilirubin measurements in Gilbert’s syndrome: method dependence. Ann Clin Biochem 2005;42:67–9. https://doi.org/10.1258/0004563053026961 . - DOI - PubMed

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