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. 2025 Jun 4;40(6):ivaf132.
doi: 10.1093/icvts/ivaf132.

Cardiac surgery-associated acute kidney injury in neonatal Norwood procedure: incidence, risk factors and impact on mortality and outcomes

Laetitia Eberle  1   2   3 , Muneaki Matsubara  1   2   3 , Jonas Palm  4 , Thibault Schaeffer  1   2   3 , Takuya Osawa  1   2   3 , Carolin Niedermaier  1   2   3 , Paul Philipp Heinisch  1   2   3 , Nicole Piber  5 , Gunter Balling  4 , Alfred Hager  4 , Peter Ewert  4 , Jürgen Hörer  1   2   3 , Masamichi Ono  1   2   3
Affiliations

Cardiac surgery-associated acute kidney injury in neonatal Norwood procedure: incidence, risk factors and impact on mortality and outcomes

Laetitia Eberle et al. Interdiscip Cardiovasc Thorac Surg. .

Abstract

Objectives: Acute kidney injury commonly complicates congenital heart surgery with cardiopulmonary bypass, increasing morbidity and mortality. This study aimed to evaluate risk factors for postoperative acute kidney injury and its impact on outcomes after the Norwood procedure.

Methods: Neonates undergoing the Norwood procedure from 2001 to 2022 were reviewed. Using modified neonatal Kidney Disease Improving Global Outcomes criteria, we assessed acute kidney injury and analysed its risk factors and impact on survival.

Results: Among the 355 patients who were included, severe acute kidney injury occurred in 100 (28.2%). Risk factors were low weight at Norwood <2.5 kg (odds ratio: 3.0, P = 0.015) and extracorporeal membrane oxygenation support (odds ratio: 2.2, P = 0.013). Shunt type was not identified as a risk (P = 0.317). Acute kidney injury was an independent risk factor for in-hospital death (odds ratio 2.3, P = 0.010) but did not influence survival after hospital discharge (hazard ratio: 1.5, P = 0.230). The hazard ratio for mortality in patients with acute kidney injury compared to patients without acute kidney injury was 2.5, P < 0.001 with a modified Blalock-Taussig-Thomas shunt and 1.9, P = 0.010 with a right ventricle-to-pulmonary artery conduit.

Conclusions: Severe acute kidney injury occurred in approximately a quarter of patients after the Norwood procedure and is an independent risk for in-hospital mortality, both in patients with a modified Blalock-Taussig-Thomas shunt and right ventricle-to-pulmonary artery conduit.

Keywords: Norwood procedure; acute kidney injury; neonates; risk factors.

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Conflict of interest statement

We have no conflicts of interest regarding the authorship, research, or publication of this manuscript.

Figures

None
Graphical abstract
Figure 1:
Figure 1:
Serum creatinine change in survivors and non-survivors in patients who developed severe AKI after the Norwood procedure. The mean values and standard error of the mean for the % change in serum creatinine from the preoperative value at the nine measurement dates are shown.
Figure 2:
Figure 2:
Overall survival after the Norwood procedure by AKI status.
See this image and copyright information in PMC

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