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. 2025 Jun 3.
doi: 10.1097/ICO.0000000000003905. Online ahead of print.

Spontaneous Artificial Corneal Endothelial Graft Reattachment: Case Report

Mechleb Nicole  1   2 , Gatinel Damien  1   2 , Saad Alain  1   2
Affiliations

Spontaneous Artificial Corneal Endothelial Graft Reattachment: Case Report

Mechleb Nicole et al. Cornea. .

Abstract

Purpose: EndoArt, a synthetic endothelial substitute for corneal edema, often requires multiple rebubbling procedures because of high detachment rates. This study reports 2 cases of spontaneous EndoArt reattachment, suggesting a potential alternative management approach.

Methods: Two patients with endothelial dysfunction underwent EndoArt implantation. Both experienced partial detachment postoperatively. Although rebubbling was considered, a conservative approach was taken, leading to spontaneous reattachment. Serial anterior segment optical coherence tomography (AS-OCT) monitored graft adherence and corneal thickness.

Results: Spontaneous reattachment occurred within 2 to 6 weeks, accompanied by progressive corneal thinning and clarity improvement. No further intervention was required, and reattachment remained stable for 6 to 8 months. These cases challenge the notion that all EndoArt detachments necessitate immediate rebubbling.

Conclusions: This is the first report of spontaneous EndoArt reattachment. Although rebubbling remains standard practice, observation may be a viable option in select cases, reducing the need for additional procedures. Further studies are needed to refine management strategies and improve outcomes.

Keywords: EndoArt; artificial endothelial graft; bullous keratopathy; endothelial dysfunction.

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Conflict of interest statement

The authors have no funding or conflicts of interest to disclose.

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