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. 2025 Jun 4;30(1):47.
doi: 10.1007/s40519-025-01747-y.

Development of the Italian clinical practice guideline on diagnosing and treating obesity in adults: scope and methodological aspects

Rocco Barazzoni  1 , Silvio Buscemi  2 , Luca Busetto  3 , Paolo Sbraccia  4 , Simona Bo  5 , Emanuele Cereda  6 , Marco Chianelli  7 , Sonja Chiappetta  8 , Riccardo Dalle Grave  9 , Walter de Caro  10 , Giovanni Docimo  11 , Giuseppe Galloro  12 , Primiano Iannone  13 , Frida Leonetti  14 , Fabrizia Lisso  15 , Maria Caterina Manca  16 , Gerardo Medea  17 , Manuela Merli  18 , Anna Maria Moretti  19 , Giuseppe Navarra  20 , Uberto Pagotto  21 , Barbara Paolini  22 , Giovanni Papa  23 , Nicola Perrotta  24 , Andrea Pession  25 , Vincenzo Pilone  26 , Vincenzo Provenzano  27 , Cecilia Ricciardi Rizzo  28 , Maurizio Santomauro  29 , Cristina Segura Garcia  30 , Federico Spandonaro  31 , Samir Sukkar  32 , Patrizia Todisco  33 , Dario Tuccinardi  34 , Andrea Vania  35 , Valentina Vanzi  36 , Riccardo Williams  37 , Iris Zani  38 , Benedetta Ragghianti  39 , Giovanni Antonio Silverii  39 , Matteo Monami  40 ; panel and Evidence Review Team for the Italian Guidelines on Surgical Treatment of Obesity
Affiliations

Development of the Italian clinical practice guideline on diagnosing and treating obesity in adults: scope and methodological aspects

Rocco Barazzoni et al. Eat Weight Disord. .

Erratum in

  • Correction: Development of the Italian clinical practice guideline on diagnosing and treating obesity in adults: scope and methodological aspects.
    Barazzoni R, Buscemi S, Busetto L, Sbraccia P, Bo S, Cereda E, Chianelli M, Chiappetta S, Grave RD, de Caro W, Docimo G, Galloro G, Iannone P, Leonetti F, Lisso F, Manca MC, Medea G, Merli M, Moretti AM, Navarra G, Pagotto U, Paolini B, Papa G, Perrotta N, Pession A, Pilone V, Provenzano V, Rizzo CR, Santomauro M, Garcia CS, Spandonaro F, Sukkar S, Todisco P, Tuccinardi D, Vania A, Vanzi V, Williams R, Zani I, Ragghianti B, Silverii GA, Monami M; panel and Evidence Review Team for the Italian Guidelines on Surgical Treatment of Obesity. Barazzoni R, et al. Eat Weight Disord. 2025 Aug 21;30(1):68. doi: 10.1007/s40519-025-01776-7. Eat Weight Disord. 2025. PMID: 40839089 Free PMC article. No abstract available.

Abstract

Overweight and obesity are substantial, growing public health concerns due to their huge direct and indirect negative impact on health. Obesity-associated complications and comorbid conditions include metabolic, cardiovascular, renal, liver and respiratory diseases, cancers, and functional limitations, leading to higher all-cause and cardiovascular mortality, and incident disability. The development of rigorous guidelines considering and comparing all possible therapeutic strategies is of critical importance, and a relevant tool for improving the quality of care and increasing the appropriateness of therapeutic choices. The Italian National Institute of Health (ISS-Istituto Superiore di Sanità) appointed the Italian Obesity Society (SIO-Società Italiana dell'Obesità) and other key scientific societies with a relevant stakeholder role on the theme issue to design and develop a new Italian guideline for the management of obesity in adult subjects, aimed at assisting healthcare professionals in the consideration of lifestyle, pharmacological, endoscopic, and surgical options for the treatment of overweight and obesity, as well as related conditions. We adopted Grading of Recommendations, Assessment, Development and Evaluations (GRADE) methodology, strongly endorsed by Istituto Superiore di Sanità to develop trustworthy guidelines to be accepted onto Sistema Nazionale Linee Guida, the reference repository of national clinical practice guidelines for the Servizio Sanitario Nazionale.

Keywords: GRADE; Guidelines; Methods; Obesity.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This article does not contain any studies with human participants or animals performed by any of the authors. Competing interests: SB has received consultancy or speaking fees or research direct or indirect contributions from Novo Nordisk, Eli Lilly, Boehringer, Pfizer, Dompè, Bruno farmaceutici, Recordati rare diseases, Therascience, Merieux; LB has received consultancy fees from Novo Nordisk, Eli Lilly, Boehringer Ingelheim, Pfizer, Roche, Regeneron and Bruno Farmaceutici and speaking fees from Rythms Pharmaceuticals and Pronokal; EM has received consultancy fees from Merck and Novartis speaking fees from Astra Zeneca, Bristol Myers Squibb, Boehringer-Ingelheim, Eli-Lilly, Merck, Novo Nordisk, Sanofi, and Novartis and research grants from Merck, Novartis, and Takeda. CC and LN have no relevant conflicts of interest to declare. MM has received speaking fees from Astra Zeneca, Bristol Myers Squibb, Boehringer-Ingelheim, Eli-Lilly, Merck, Novo Nordisk, Sanofi, and Novartis and research grants from Bristol Myers Squibb; PS received payment of honoraria and consulting fees from Boehringer Ingelheim, Chiesi, Novo Nordisk, Eli Lilly, Pfizer, and Roche as a member of advisory boards. All the other authors have no relevant COI to declare.

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