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Case Reports
. 2025 Aug;52(8):533-538.
doi: 10.1111/cup.14828. Epub 2025 Jun 4.

Primary Cutaneous SMARCA4-Deficient Tumor With Metastases

Supriya Pradhan  1 , Martha Lehman  2 , Abdul Mohd Tahir  3 , Michael Su  4 , Steven Kossard  2 , Renukadas Sakalkale  1
Affiliations
Case Reports

Primary Cutaneous SMARCA4-Deficient Tumor With Metastases

Supriya Pradhan et al. J Cutan Pathol. 2025 Aug.

Abstract

SMARCA-4 deficient cutaneous tumor is extremely uncommon. These are aggressive tumors to begin with, and should be recognised at the outset from their extremely high-grade morphology and absence or extreme paucity of not only usual carcinoma markers but also complete absence of SMARCA-4, which should be performed. We present such a case with extensive metastases, notable for relatively quite small size of primary skin lesion. The case must be evaluated in full to rule out systemic including thoraco-visceral disease.

Keywords: SMARCA4; SMARCA4‐deficient undifferentiated malignant neoplasm; metastases; skin tumor; undifferentiated skin tumor.

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References

    1. E. Russell‐Goldman, L. MacConaill, and J. Hanna, “Primary Cutaneous SMARCA4‐Deficient Undifferentiated Malignant Neoplasm: First Two Cases With Clinicopathologic and Molecular Comparison to Eight Visceral Counterparts,” Modern Pathology 35, no. 12 (2022): 1821–1828.
    1. E. Gumusgoz, B. S. Graham, and G. A. Hosler, “Primary Cutaneous SMARCA4‐Deficient Undifferentiated Malignant Neoplasm: A Rare Case Report and Literature Review,” Journal of Cutaneous Pathology 51, no. 4 (2024): 262–266, https://doi.org/10.1111/cup.14576.
    1. N. Rekhtman, J. Montecalvo, J. C. Chang, et al., “SMARCA4‐Deficient Thoracic Sarcomatoid Tumors Represent Primarily Smoking‐Related Undifferentiated Carcinomas Rather Than Primary Thoracic Sarcomas,” Journal of Thoracic Oncology 15 (2020): 231–247, https://doi.org/10.1016/j.jtho.2019.10.023.
    1. X. Wang, J. R. Haswell, and C. W. Roberts, “Molecular Pathways: SWI/SNF (BAF) Complexes Are Frequently Mutated in Cancer—Mechanisms and Potential Therapeutic Insights,” Clinical Cancer Research 20, no. 1 (2014): 21–27, https://doi.org/10.1158/1078‐0432.CCR‐13‐0280.
    1. C. R. Clapier and B. R. Cairns, “The Biology of Chromatin Remodeling Complexes,” Annual Review of Biochemistry 78 (2009): 273–304, https://doi.org/10.1146/annurev.biochem.77.062706.153223.

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