Acquired Piezo2 Channelopathy is One Principal Gateway to Pathophysiology

Abstract

The Piezo2 transmembrane proteins were identified by Ardem Patapoutian and his team. They also found that Piezo2 is the principal mechanosensory ion channel responsible for proprioception. Even before the Nobel Prize was awarded to him, it was proposed that these Piezo2 channels could sustain acquired microdamage at the proprioceptive somatosensory terminals under allostatic stress. Moreover, the principality of Piezo2 is suggested to extend beyond its physiological function, highlighting its relevance in the context of microdamage as well. Hence, acquired Piezo2 channelopathy is proposed to constitute one principal gateway to pathophysiology underpinned by proton affinity, energy metabolism and a proprioceptive pathway switch. The differentiating incomparable hallmark of Piezo2 is theorized to be a low-frequency semiconductor Schottky barrier diode-like feature that provides proton handling for quantum tunnelling and ultrafast long-range signalling to the hippocampus. Accordingly, even the proposed acquired Piezo2 channelopathy is also enigmatic by causing the impairment of this Piezo2-initiated ultrafast proton-based long-range signalling and proper synchronization to the hippocampus. The revealing of this protonic word and the ultrafast long-range signalling within the nervous system and its microdamage brings an entirely new perspective in medicine with the interpretation of the quad-phasic non-contact injury model. This is why this Piezo2 microdamage has been coined as the primary damage or the root cause of ageing. Paired-associative electromagnetic stimulation appears to be a promising treatment method and heart rate variability detection could be used for diagnosing autonomic nervous system disbalance as one symptom of this proposed Piezo2 channelopathy.

Keywords: Piezo2; channelopathy; proprioception; proton; quad-phasic non-contact injury model; ultrafast long-range neurotransmission.