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. 2025 Jul;27(7):856-870.
doi: 10.1007/s11912-025-01690-2. Epub 2025 Jun 4.

Retroperitoneal Sarcoma (RPS): A Systematic Review

Ilaria Caturegli  1 , Elizabeth J Lilley  2 , Mark Fairweather  2 , Jiping Wang  2 , Chandrajit P Raut  2
Affiliations

Retroperitoneal Sarcoma (RPS): A Systematic Review

Ilaria Caturegli et al. Curr Oncol Rep. 2025 Jul.

Abstract

Retroperitoneal sarcomas (RPS) are a group of rare malignancies with many histologic types. Surgery is the hallmark of curative therapy for non-metastatic disease with the extent of resection depending on the histology. RECENT FINDINGS: Neoadjuvant therapies have limited response and efficacy in RPS; however, the benefit, regimen, and timing depend on histology. Innovative therapeutics are emerging and may prove promising. PURPOSE OF REVIEW: This review discusses the work-up, management, and advances in the field of retroperitoneal sarcoma.

Keywords: Leiomyosarcoma; Liposarcoma; Radiation therapy; Retroperitoneal sarcoma.

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Conflict of interest statement

Declarations. Human and Animal Rights: All reported studies with human subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines). Competing Interests: The authors declare no competing interests.

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