Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2025 Jun 2;71(4):e20240411.
doi: 10.1590/1806-9282.20240411. eCollection 2025.

Comparison of inflammatory indices in patients with metastatic non-small cell lung cancer

Zuhat Urakçı  1 , Zeynep Oruc  1 , Halil Kömek  2 , Senar Ebinç  1 , Esra Pirinççi  3 , Ziya Kalkan  1 , Bekir Taşdemir  4 , Muhammet Ali Kaplan  1 , Mehmet Küçüköner  1 , Abdurrahman Işıkdoğan  1
Affiliations
Comparative Study

Comparison of inflammatory indices in patients with metastatic non-small cell lung cancer

Zuhat Urakçı et al. Rev Assoc Med Bras (1992). .

Abstract

Objective: The aim of this study was to compare the prognostic value of inflammatory indices, including the prognostic nutritional index, advanced lung cancer inflammation index, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, Glasgow Prognostic Score, and C-reactive protein/albumin ratio, in patients with metastatic non-small cell lung cancer and to determine whether any of the indices are correlated.

Methods: The demographic, clinicopathological, and laboratory data of 179 patients with metastatic non-small cell lung cancer who presented to our medical oncology clinic between 2014 and 2021 were retrospectively obtained from the hospital database system.

Results: Among the inflammatory indices, C-reactive protein/albumin ratio (p=0.002), advanced lung cancer inflammation index (p=0.04), and neutrophil/lymphocyte ratio (p=0.008) were associated with overall survival. Multivariate overall survival analysis showed that Eastern Cooperative Oncology Group Performance Status score (HR 1.37; 95%CI 1.06-1.77; p=0.016) and C-reactive protein/albumin ratio (HR 1.13; 95%CI 1.03-1.24; p=0.01) were independent prognostic factors associated with overall survival. Patients with a high and low C-reactive protein/albumin ratio differed statistically significantly in terms of gender, histopathological subtype, history of smoking, and metastatic site (p<0.05). Correlation analysis showed that C-reactive protein/albumin ratio was negatively correlated with advanced lung cancer inflammation index (r=-0.433, p<0.001) and positively correlated with the other four indices (neutrophil/lymphocyte ratio: r=0.368, p<0.001; platelet/lymphocyte ratio: r=0.321, p<0.001; Glasgow Prognostic Score: r=0.537, p<0.001; and prognostic nutritional index: r=0.223, p=0.003).

Conclusion: Our findings show that among the investigated inflammatory indices, C-reactive protein/albumin ratio has the highest prognostic value in patients with metastatic non-small cell lung cancer.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest: the authors declare there is no conflicts of interest.

References

    1. Huang J, Deng Y, Tin MS, Lok V, Ngai CH, Zhang L, et al. Distribution, risk factors, and temporal trends for lung cancer incidence and mortality: a global analysis. Chest. 2022;161(4):1101–1111. doi: 10.1016/j.chest.2021.12.655. - DOI - PubMed
    1. Meira DD, Castro E, Caetano MC, Casotti MC, Zetum ASS, Gonçalves AFM, Moreira AR, et al. Prognostic factors and markers in non-small cell lung cancer: recent progress and future challenges. Genes (Basel) 2023;14(10):1906–1906. doi: 10.3390/genes14101906. - DOI - PMC - PubMed
    1. Mazzella A, Maiolino E, Maisonneuve P, Loi M, Alifano M. Systemic inflammation and lung cancer: is it a real paradigm? Prognostic value of inflammatory indexes in patients with resected non-small-cell lung cancer. Cancers (Basel) 2023;15(6):1854–1854. doi: 10.3390/cancers15061854. - DOI - PMC - PubMed
    1. Chantharakhit C, Sujaritvanichpong N. Prognostic impact of the advanced lung cancer inflammation index (ALI) in metastatic non-small cell lung cancer treated with first line chemotherapy. Asian Pac J Cancer Prev. 2021;22(4):1149–1156. doi: 10.31557/APJCP.2021.22.4.1149. - DOI - PMC - PubMed
    1. Wang J, Liu Y, Mi X, Shao M, Liu L. The prognostic value of prognostic nutritional index (PNI) and neutrophil to lymphocyte ratio (NLR) for advanced non-small cell lung cancer treated with platinum-based chemotherapeutics. Ann Palliat Med. 2020;9(3):967–978. doi: 10.21037/apm.2020.04.31. - DOI - PubMed

Publication types

MeSH terms