Funding Support and Author Disclosures Dr Jessup is employed by the American Heart Association. Dr Adamson is an employee of Abbott. Dr Vaduganathan has received research grant support from or served on the advisory boards of American Regent, Amgen, AstraZeneca, Bayer, Baxter Healthcare, Boehringer Ingelheim, Cytokinetics, Lexicon Pharmaceuticals, Novartis, Pharmacosmos, Relypsa, Roche Diagnostics, and Sanofi; has reported speaker engagements with Novartis and Roche Diagnostics; and has served on clinical endpoint committees for studies sponsored by Bayer, Galmed, Novartis, Occlutech, and Impulse Dynamics. Dr Lindenfeld has received consulting fees, research support, and/or personal fees from Abbott, Alleviant, AstraZeneca, Boehringer Ingelheim, Boston Scientific, CVRx, Edwards Lifesciences, Impulse Dynamics, Sensible Medical, V-WAVE, Vifor, and VoluMetrix. Dr Yancy has reported spousal salary support from Abbott Laboratories. Dr O’Connor has reported serving as a consultant for Bayer, Merck, and Abiomed. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.