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. 2025 Jun 3;37(6):1247-1249.
doi: 10.1016/j.cmet.2025.05.002.

Monoclonal antibody therapy for PCOS?

David H Abbott  1 , Daniel A Dumesic  2
Affiliations

Monoclonal antibody therapy for PCOS?

David H Abbott et al. Cell Metab. .

Abstract

There is no cure for polycystic ovary syndrome (PCOS), only treatment for its highly prevalent reproductive, cardiometabolic, and psychological symptoms. Early signs of PCOS appear during infancy. This enabled Cotellessa et al.1 to develop and administer neutralizing antibody therapy during infancy in a female mouse model to eradicate PCOS symptomology.

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Conflict of interest statement

Declaration of interests D.H.A. is a consultant for Alnylam Pharmaceuticals, Inc., and D.A.D. has consulted for Spruce Biosciences, Inc.; Precede Biosciences, Inc.; Ferring Research Institute; Ferring Pharmaceuticals; and Organon LLC.

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