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Comment
. 2025 Jun 3;37(6):1250-1251.
doi: 10.1016/j.cmet.2025.05.003.

Time to exercise! Boosting exercise performance via AMPK signaling

Tinh-Hai Collet  1 , Charna Dibner  2
Affiliations
Comment

Time to exercise! Boosting exercise performance via AMPK signaling

Tinh-Hai Collet et al. Cell Metab. .

Abstract

Body physiology follows the daily rhythm driven by the circadian system, which underlies the emerging concept of chrono-medicine. In this issue, Chen et al.1 report that feeding timing modulates adipocyte AMP-activated protein kinase (AMPK) α2 signaling to enhance exercise performance in mice, paving the way for chronotherapeutic approaches of AMPK activators such as metformin.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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