MRI-Guided Focused Ultrasound (MRgFUS) in Parkinson's Disease and Essential Tremor: Incisionless but Invasive! - A Narrative Review

Abstract

Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging and promising technology for treating movement disorders, such as essential tremor and tremor-dominant Parkinson's disease. It utilises advanced ultrasound transducer emitters to condense sound waves at a precisely defined point able to target various brain areas, such as the pallidothalamic tract, thalamus, and pallidum that ameliorates some of the symptoms of Parkinson's disease and other movement disorders like dystonic and action induced tremors. we review the current status of preclinical and clinical trials clinical use, treatment outcomes and indications of Magnetic resonance-guided focused ultrasound (MRgFUS).

Keywords: Essential Tremor; High-intensity focused ultrasound ablation; Magnetic resonance-guided focused ultrasound (MRgFUS); Tremor dominant Parkinson’s disease; blood-brain-barrier.