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Case Reports
. 2025 Jun 2:19:e20250292.
doi: 10.1590/1980-5764-DN-2025-0292. eCollection 2025.

Visual field defect as the first manifestation of Alzheimer's disease

Marcelo Houat de Brito  1 , Artur Martins Coutinho  2 , Carla Rachel Ono  2 , Eduardo Sturzeneker Trés  1 , Sonia Maria Dozzi Brucki  1
Affiliations
Case Reports

Visual field defect as the first manifestation of Alzheimer's disease

Marcelo Houat de Brito et al. Dement Neuropsychol. .
No abstract available

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Conflict of interest statement

Disclosure: The authors report no conflicts of interest.

Figures

Figure 1
Figure 1. Computerized Visual Field Grayscale Map. Humphrey Visual Field Analyzer SITA-based central 24-2 threshold test demonstrating a bilateral peripheral visual field defect (macular sparing pattern), predominantly affecting the right hemifields. Fixation loss, false-positive, and false-negative response rates were within reliable limits.
Figure 2
Figure 2. [18F]FDG and [11C] PiB–PET/MRI. (A1) [18F]FDG-PET/MRI: left-predominant bilateral hypometabolism in the occipital and temporo-occipital areas (arrows). (A2) Left sagittal MRI (FLAIR): no structural abnormalities detected. (A3) [18F]FDG-PET 3D-SSP images (Cortex ID suite, GE Healthcare). (A4) Z-score projection of hypometabolism. (B1) [11C]PiB-PET/MRI: diffuse cortical amyloid deposition – transaxial, coronal and sagittal views (B1) and 3D-SSP (B2).
See this image and copyright information in PMC

References

    1. Shir D, Graff-Radford J, Machulda MM, Pham NTT, Jack CR, Jr, Lowe VJ, et al. Posterior cortical atrophy: Primary occipital variant. Eur J Neurol. 2022;29(7):2138–2143. doi: 10.1111/ene.15327. - DOI - PMC - PubMed
    1. Pelak VS, Smyth SF, Boyer PJ, Filley CM. Computerized visual field defects in posterior cortical atrophy. Neurology. 2011;77(24):2119–2122. doi: 10.1212/WNL.0b013e31823e9f2a. - DOI - PubMed

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