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Case Reports
. 2025 Jun 4;12(6):e01720.
doi: 10.14309/crj.0000000000001720. eCollection 2025 Jun.

Esophageal Granular Cell Tumor Associated With Eosinophilic Gastrointestinal Disease

Cathy Zheng  1   2 , Robert Mowery  3 , Sareena Ali  3 , Camilla Allen  4 , Ryan T Hoff  2   4
Affiliations
Case Reports

Esophageal Granular Cell Tumor Associated With Eosinophilic Gastrointestinal Disease

Cathy Zheng et al. ACG Case Rep J. .

Abstract

Granular cell tumors (GCTs) are typically benign lesions that can occur in the gastrointestinal tract. Eosinophilic gastrointestinal disease, including eosinophilic esophagitis (EoE), is an immune-mediated condition characterized by eosinophil-predominant inflammation in the gastrointestinal tract. We review previously reported cases of EoE associated with GCTs. To our knowledge, we present the first case of esophageal GCT in a patient with a long history of eosinophilic gastrointestinal disease and likely several years of active EoE before esophageal GCT diagnosis.

Keywords: eosinophilic esophagitis; eosinophilic gastrointestinal disease; esophagus; granular cell tumor.

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Figures

Figure 1.
Figure 1.
Image from initial upper endoscopy showing esophageal granular cell tumor at 31 cm from the incisors, which appears sessile and white. Nearby mucosa shows esophageal exudates (eosinophilic microabscesses).
Figure 2.
Figure 2.
Image from initial upper endoscopy showing longitudinal furrows. Eosinophilic esophagitis endoscopic reference score: E1 R0 Ex1 F1 S0.
Figure 3.
Figure 3.
Eosinophilic esophagitis. Note the red eosinophils infiltrating the epithelium (black arrows). Magnification 200×.
Figure 4.
Figure 4.
(A) Granular cell tumor positive for S-100 immunohistochemical stain with 100× magnification. (B) Granular cell tumor with epithelioid features characterized by large cells with abundant pink, granular cytoplasm due to numerous lysosomes. Black outline shows cytoplasm of GCT cell. Red arrows show GCT nuclei. 200× magnification. (C) Granular cell tumor showing overlying squamous mucosa. Note that the GCT (red bar) does not invade into the mucosa (black bar). Magnification 100×. GCT, granular cell tumors.
See this image and copyright information in PMC

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