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. 2025 Apr 13;4(3):e70028.
doi: 10.1002/imt2.70028. eCollection 2025 Jun.

Enhancing human gut health: Global innovations in dysbiosis management

Reda El Boukhari  1 , Maima Matin  2 , Latifa Bouissane  3 , Michał Ławiński  2   4 , Oleh Lushchak  5   6 , Rajeev K Singla  7   8 , Michel-Edwar Mickael  2 , Jordi Mayneris-Perxachs  9   10   11 , Maria Eleni Grafakou  12 , Shuhua Xu  13   14 , Bowen Liu  15 , Jiayi Guan  16 , Andrzej Półtorak  17 , Arkadiusz Szpicer  17 , Agnieszka Wierzbicka  2   17 , Nikolay T Tzvetkov  18 , Maciej Banach  19   20   21   22 , Jarosław Olav Horbańczuk  2 , Artur Jóźwik  2 , Marco Cascella  23 , Bairong Shen  24   25 , Vasil Radoslavov Pirgozliev  26 , Dongdong Wang  27   28 , Olena Litvinova  29   30 , Olga Adamska  31 , Agnieszka Kamińska  31 , Marcin Łapiński  32 , Artur Stolarczyk  32 , Ioana Berindan-Neagoe  33 , Luigi Milella  34 , Andy Wai Kan Yeung  35 , Prashanth Suravajhala  36   37 , Anupam Bishayee  38 , Ronan Lordan  39 , Laszlo Barna Iantovics  40 , Ricardo Lagoa  41   42 , Monika Michalczuk  43 , Jivko Stoyanov  44   45 , A Douglas Kinghorn  46 , Banaz Jalil  47 , Wolfram Weckwerth  48   49 , Bey Hing Goh  50   51   52 , Meng-Yao Li  53   54 , Gyaneshwer Chaubey  55 , Gian Luigi Russo  56 , Sara Frazzini  57 , Luciana Rossi  57 , Maurizio Battino  58   59   60 , Wei Jia  61 , Qi Su  62   63 , Xiaoqiang Ma  64 , Judith M Rollinger  65 , Simon K-M R Rittmann  66 , Helen Sheridan  67   68 , John J Walsh  67 , Gérard Lizard  68 , Tomasz M Karpiński  69 , Ana Sanches Silva  70   71 , Jakub Piwowarski  72 , Liwei Xie  73   74 , Tai-Ping Fan  74 , Francesca Giampieri  58   59   75   76 , Adil El Midaoui  77   78 , Ka-Hing Wong  79   80 , Ren-You Gan  79   80 , Ahmed Fatimi  1 , Atanas G Atanasov  2   30   81
Affiliations

Enhancing human gut health: Global innovations in dysbiosis management

Reda El Boukhari et al. Imeta. .

Abstract

The microbiota, comprising all the microorganisms within the body, plays a critical role in maintaining good health. Dysbiosis represents a condition resulting from an imbalance or alteration of the microbiota. This study comprehensively investigates the patent literature on dysbiosis over the past 20 years.

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Conflict of interest statement

The authors declare no conflicts of interest. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in this article.

Figures

Figure 1
Figure 1
The global patent landscape of inventions related to dysbiosis. (A) Evolution of the dysbiosis patent publication since 2005 (the year 2024 data are limited to October 28). (B) Current legal status of dysbiosis patent documents. (C) Top 10 dysbiosis patent documents jurisdictions. (D) Top 10 dysbiosis patent documents owners.
Figure 2
Figure 2
Dysbiosis‐related data based on relevant diseases, most cited patents and publications, and innovation fields. (A) The most dysbiosis‐associated diseases. (B) The top 10 most cited dysbiosis patent documents. (C) The top 10 scientific publications that are most cited in the dysbiosis patent documents. (D) Innovation fields based on the dysbiosis patent document IPC codes.
See this image and copyright information in PMC

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