Are the outcomes of critically ill children undergoing pediatric continuous kidney replacement therapy actually modifiable?

Francesco Guzzi¹, Zaccaria Ricci^{2

3}

Affiliations

¹ Nephrology and Dialysis Unit, Department of Medical Specialties, Azienda USL Toscana Centro, Prato, Italy.
² Pediatric Intensive Care Unit, Meyer Children's Hospital, IRCCS, Florence, Italy. zaccaria.ricci@unifi.it.
³ Department of Health Science, Section of Anesthesia and Intensive Care, University of Florence, Piazza Di San Marco 4, Florence, Italy. zaccaria.ricci@unifi.it.

Editorial

Francesco Guzzi et al. Pediatr Nephrol. 2025.

. 2025 Jun 5.

doi: 10.1007/s00467-025-06836-9. Online ahead of print.

Francesco Guzzi¹, Zaccaria Ricci^{2

3}

¹ Nephrology and Dialysis Unit, Department of Medical Specialties, Azienda USL Toscana Centro, Prato, Italy.
² Pediatric Intensive Care Unit, Meyer Children's Hospital, IRCCS, Florence, Italy. zaccaria.ricci@unifi.it.
³ Department of Health Science, Section of Anesthesia and Intensive Care, University of Florence, Piazza Di San Marco 4, Florence, Italy. zaccaria.ricci@unifi.it.

No abstract available

References

1. Frisby-Zedan J, Barhight M, Chen W, Keswani M (2025) Risk factors for adverse short-term and long-term outcomes in children with severe acute kidney injury requiring continuous kidney replacement therapy. Pediatr Nephrol. https://doi.org/10.1007/s00467-025-06753-x - DOI - PubMed
1. Sutherland SM, Zappitelli M, Alexander SR et al (2010) Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry. Am J Kidney Dis 55:316–325. https://doi.org/10.1053/j.ajkd.2009.10.048 - DOI - PubMed
1. Alobaidi R, Morgan C, Basu RK et al (2018) Association between fluid balance and outcomes in critically ill children: a systematic review and meta-analysis. JAMA Pediatr 172:257–268. https://doi.org/10.1001/jamapediatrics.2017.4540 - DOI - PubMed - PMC
1. Cortina G, McRae R, Hoq M et al (2019) Mortality of critically ill children requiring continuous renal replacement therapy: effect of fluid overload, underlying disease, and timing of initiation. Pediatr Crit Care Med 20:314–322. https://doi.org/10.1097/PCC.0000000000001806 - DOI - PubMed
1. Selewski DT, Barhight MF, Bjornstad EC et al (2024) Fluid assessment, fluid balance, and fluid overload in sick children: a report from the Pediatric Acute Disease Quality Initiative (ADQI) conference. Pediatr Nephrol 39:955–979. https://doi.org/10.1007/s00467-023-06156-w - DOI - PubMed