Conference Report: Cerebellar Development and Disease at Single-Cell Resolution

Lena M Kutscher¹, Davide Aprile², N Sumru Bayin^{3

4}, Esther B E Becker^{5

6}, Valentina Cerrato^{7

8}, Giacomo Turrini^{7

8}, Marion Coolen⁹, Vincent Cantagrel⁹, Béatrice C Durand¹⁰, Myron K Evans Ii^{11

12}, Parthiv Haldipur¹³, Kathleen J Millen¹³, Joanna Yeung^{14

15}, Daniel Goldowitz^{14

15}, Mary E Hatten¹⁶, Alexandra L Joyner¹⁷, Justus M Kebschull^{18

19}, James Y H Li^{20

21}, Giorgia Quadrato^{22

23}, Christin Schmidt²⁴, Mari Sepp²⁵, Teresa P Silva²⁶, Giuseppe Testa^{2

27}, Luca Tiberi²⁸, Simone Mayer^{29

30}

Affiliations

¹ Developmental Origins of Pediatric Cancer Junior Research Group, Hopp Children's Cancer Center (KiTZ) and German Cancer Research Center (DKFZ), Heidelberg, Germany. l.kutscher@kitz-heidelberg.de.
² Human Technopole, Viale Rita Levi-Montalcini 1, 20157, Milan, Italy.
³ Gurdon Institute, University of Cambridge, Cambridge, UK.
⁴ Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
⁵ Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
⁶ Kavli Institute of Nanoscience Discovery, University of Oxford, Oxford, UK.
⁷ Department of Neuroscience Rita LeviMontalcini, University of Turin, Turin, Italy.
⁸ Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy.
⁹ Developmental Brain Disorders Laboratory, Imagine Institute, INSERM UMR 1163, Université Paris Cité, Paris, France.
¹⁰ Sorbonne Université, CNRS UMR8263, Institut de Biologie Paris-Seine (IBPS) - "Développement, Adaptation et Vieillissement" (Dev2A), Paris, France.
¹¹ Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA.
¹² Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
¹³ Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
¹⁴ Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
¹⁵ Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
¹⁶ Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY, USA.
¹⁷ Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹⁸ Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
¹⁹ Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
²⁰ Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, USA.
²¹ Institute for Systems Genomics, University of Connecticut, Farmington, CT, USA.
²² Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
²³ Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
²⁴ Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
²⁵ Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany.
²⁶ Developmental Biology and Cancer Department, UCL GOS Institute of Child Health, London, UK.
²⁷ Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
²⁸ Armenise-Harvard Laboratory of Brain Cancer, University of Trento, Trento, Italy.
²⁹ Karlsruhe Institute of Technology, Zoological Institute, Karlsruhe, Germany. simone.mayer@kit.edu.
³⁰ Karlsruhe Institute of Technology, Institute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Karlsruhe, Germany. simone.mayer@kit.edu.

PMID: 40471378
PMCID: PMC12141159
DOI: 10.1007/s12311-025-01864-5

Conference Report: Cerebellar Development and Disease at Single-Cell Resolution

Lena M Kutscher et al. Cerebellum. 2025.

. 2025 Jun 5;24(4):109.

doi: 10.1007/s12311-025-01864-5.

Authors

Affiliations

¹ Developmental Origins of Pediatric Cancer Junior Research Group, Hopp Children's Cancer Center (KiTZ) and German Cancer Research Center (DKFZ), Heidelberg, Germany. l.kutscher@kitz-heidelberg.de.
² Human Technopole, Viale Rita Levi-Montalcini 1, 20157, Milan, Italy.
³ Gurdon Institute, University of Cambridge, Cambridge, UK.
⁴ Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
⁵ Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
⁶ Kavli Institute of Nanoscience Discovery, University of Oxford, Oxford, UK.
⁷ Department of Neuroscience Rita LeviMontalcini, University of Turin, Turin, Italy.
⁸ Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy.
⁹ Developmental Brain Disorders Laboratory, Imagine Institute, INSERM UMR 1163, Université Paris Cité, Paris, France.
¹⁰ Sorbonne Université, CNRS UMR8263, Institut de Biologie Paris-Seine (IBPS) - "Développement, Adaptation et Vieillissement" (Dev2A), Paris, France.
¹¹ Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA.
¹² Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
¹³ Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
¹⁴ Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
¹⁵ Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
¹⁶ Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY, USA.
¹⁷ Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
¹⁸ Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
¹⁹ Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
²⁰ Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, USA.
²¹ Institute for Systems Genomics, University of Connecticut, Farmington, CT, USA.
²² Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
²³ Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
²⁴ Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
²⁵ Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany.
²⁶ Developmental Biology and Cancer Department, UCL GOS Institute of Child Health, London, UK.
²⁷ Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
²⁸ Armenise-Harvard Laboratory of Brain Cancer, University of Trento, Trento, Italy.
²⁹ Karlsruhe Institute of Technology, Zoological Institute, Karlsruhe, Germany. simone.mayer@kit.edu.
³⁰ Karlsruhe Institute of Technology, Institute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Karlsruhe, Germany. simone.mayer@kit.edu.

PMID: 40471378
PMCID: PMC12141159
DOI: 10.1007/s12311-025-01864-5

No abstract available

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Conflict of interest statement

Declarations. Competing Interests: The authors declare no competing interests.

References

1. Mätlik K, Govek E-E, Paul MR, Allis CD, Hatten ME. Histone bivalency regulates the timing of cerebellar granule cell development. Genes Dev. 2023;37:570–89. - PMC - PubMed
1. Hanzel M, Fernando K, Maloney SE, Horn Z, Gong S, Mätlik K, et al. Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties. Proc Natl Acad Sci U S A. 2024;121:e2405901121. - PMC - PubMed
1. Kebschull JM, Richman EB, Ringach N, Friedmann D, Albarran E, Kolluru SS, et al. Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set. Science. 2020;370:eabd5059. - PMC - PubMed
1. Fujita H, Kodama T, du Lac S. Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis. Elife. 2020;9:e58613. - PMC - PubMed
1. Willett RT, Bayin NS, Lee AS, Krishnamurthy A, Wojcinski A, Lao Z, et al. Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic purkinje cell number and organ growth. Elife. 2019;8:e50617. - PMC - PubMed

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Conference Report: Cerebellar Development and Disease at Single-Cell Resolution

Affiliations

Conference Report: Cerebellar Development and Disease at Single-Cell Resolution

Authors

Affiliations

Conflict of interest statement

References

Grants and funding

LinkOut - more resources

Full Text Sources