Budding trends in nanofibers for topical delivery of therapeutics for the treatment of vitiligo

Abstract

Nanofibers have been investigated for the possible topical delivery of medicines, one of the nanostructure-based drug delivery strategies produced by nanotechnology. Filaments or thread-like structures in the nanometer size range are called nanofibers, and they are made from a variety of polymers, including synthetic and natural polymers, or a combination of both. The polymers, preparation methods, and design specifications all affect the nanofibers' diameter or size. When creating nanofibers, the four main processing methods phase separation, self-assembly, template synthesis, and electrospinning are most frequently employed. The morphology and characterization parameters of nanofibers require a multimethod approach due to their unique structure. Large-scale manufacturing of nanofibers with the required qualities is still problematic, though, because popular electrospinning techniques have drawbacks like low yield, high voltage requirements, and trouble accomplishing in situ nanofiber deposition on different substrates. This study focuses on the latest clinical trials, applications, production techniques, and patents of nanofibers for vitiligo. They are becoming more popular as drug delivery vehicles, and the skin's enormous surface area makes it a potentially effective method for topical medication solutions for a variety of skin conditions, including vitiligo, psoriasis, skin cancer, wounds, bacterial and fungal infections, etc.

Keywords: Nanofibers; method; patent; topical; vitiligo.