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Review
. 2025 May 22:16:1586238.
doi: 10.3389/fphar.2025.1586238. eCollection 2025.

Food plants as adjuvant medicines: a review of protective effects and clinical potential in alcoholic liver disease

Chenyu Li #  1   2 , Qi Zhang #  1 , Zijun Chen  2   3 , Weiming Hu  2   4 , Fen Liu  2
Affiliations
Review

Food plants as adjuvant medicines: a review of protective effects and clinical potential in alcoholic liver disease

Chenyu Li et al. Front Pharmacol. .

Abstract

Research background: Globally, alcohol usage is the third-leading risk factor for diseases, and alcohol-induced alcoholic liver disease (ALD) has become a global public health problem. ALD is characterized by oxidative stress and immune damage in the liver caused by excessive alcohol consumption. Furthermore, alcohol and its metabolites disrupt the health of the intestinal tract and cause secondary liver damage through the gut-liver axis.

Existing problems: The underlying mechanisms of ALD are complex. Currently, there are no safe and effective drugs for the prevention and treatment of ALD; some food plants used as medicines (FPUM) have demonstrated promising effects in combating this condition.

Solutions: In this review, we analyze the pathogenesis of ALD and explore the mechanisms of action of certain FPUM in preventing and treating ALD. Different mechanisms include activation of alcohol metabolism-related enzymes, maintenance of mitochondrial stability, reduction of oxidative stress damage caused by alcohol intake, regulation of cytokine levels, and modulation of the gut microbiota. The review also explores potential future research directions and summarizes insights for developing novel therapeutic agents and components.

Future prospects: Future research on FPUM for the treatment of ALD could explore promising avenues such as multi-herb combinations, multi-component formulations, and side effect reduction strategies, demonstrating that the development of herbal medicine still holds boundless potential.

Keywords: alcoholic liver disease; food plants used as medicines; mechanism of action; pathogenesis of ALD; traditional Chinese Medicine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Metabolic processes involved in the oxidative conversion of alcohol.
FIGURE 2
FIGURE 2
Schematic diagram of hepatocyte interaction in ALD.
FIGURE 3
FIGURE 3
The working principle of FPUM in the treatment of ALD.
See this image and copyright information in PMC

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References

    1. Albillos A., de Gottardi A., Rescigno M. (2020). The gut-liver axis in liver disease: pathophysiological basis for therapy. J. Hepatol. 72 (3), 558–577. 10.1016/j.jhep.2019.10.003 - DOI - PubMed
    1. Allaire M., Rautou P. E., Codogno P., Lotersztajn S. (2019). Autophagy in liver diseases: time for translation? J. Hepatol. 70 (5), 985–998. 10.1016/j.jhep.2019.01.026 - DOI - PubMed
    1. Ambade A., Lowe P., Kodys K., Catalano D., Gyongyosi B., Cho Y., et al. (2019). Pharmacological inhibition of CCR2/5 signaling prevents and reverses Alcohol-induced liver damage, steatosis, and inflammation in mice. Hepatology 69 (3), 1105–1121. 10.1002/hep.30249 - DOI - PMC - PubMed
    1. Arab J. P., Sehrawat T. S., Simonetto D. A., Verma V. K., Feng D., Tang T., et al. (2020). An open-Label, dose-Escalation study to assess the safety and efficacy of IL-22 agonist F-652 in patients with alcohol-associated Hepatitis. Hepatology 72 (2), 441–453. 10.1002/hep.31046 - DOI - PMC - PubMed
    1. Argemi J., Latasa M. U., Atkinson S. R., Blokhin I. O., Massey V., Gue J. P., et al. (2019). Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Nat. Commun. 10 (1), 3126. 10.1038/s41467-019-11004-3 - DOI - PMC - PubMed

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