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Review
. 2023;5(1):17.
doi: 10.1186/s43014-023-00133-4. Epub 2023 Apr 6.

A review on the immunomodulatory properties of functional nutraceuticals as dietary interventions for children to combat COVID-19 related infections

Swati Soni  1 , Kuppusamy Alagesan Paari  1
Affiliations
Review

A review on the immunomodulatory properties of functional nutraceuticals as dietary interventions for children to combat COVID-19 related infections

Swati Soni et al. Food Prod Process Nutr. 2023.

Abstract

COVID-19 is a significant threat to humanity in the present day due to the rapid increase in the number of infections worldwide. While most children may be spared of the direct mortality effects of the disease, those with weak immune systems are prone to adverse effects. Child mortality increases due to the stress caused to the health care system that disrupts essential health care needs such as immunisation and antenatal care. The use of functional foods (FF) aids in disease-prevention as they are known to have protective effects against COVID-19 by boosting children's cellular and humoral immunity. Plant components such as glycyrrhizin, epigallocatechin gallate, allicin, and fucoidan exhibit antiviral properties against various viruses, including SARS-CoV 2. Microbial foods that are made of probiotics, can enhance immunity against various respiratory viruses. Food enriched with additives such as lactoferrin, piperine, and zinc can boost immunity against COVID-19. With proper definitive drug therapy not available for treating COVID-19 and most of the disease management tools rely on symptoms and non-specific supportive care, developing a functional paediatric formulation will prevent further deterioration in infant health. It is wise to investigate the toxicological aspects of Functional Foods components especially when formulating for children. The safe limits of ingredients should be strictly followed during FFs formulation. Stronger regulations with advanced analytical techniques can help to formulate functional foods into the mainstream in child nutraceuticals. The purpose of this review is to compile collective information on the functional nutraceuticals specifically for infants and children up to the age of 10 years that could confer immunity against COVID-19 and other related viruses.

Keywords: Antiviral; COVID 19; Food additives; Functional food; Infant food.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Structure of glycyrrhizin, a triterpenoid class of saponin found in liquorice
Fig. 2
Fig. 2
Structure of Epigallocatechin gallate
Fig. 3
Fig. 3
Structure of Allicin
Fig. 4
Fig. 4
Probiotic that possesses antiviral properties as demonstrated in adults and children
See this image and copyright information in PMC

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References

    1. Ahmadi, A., Zorofchian Moghadamtousi, S., Abubakar, S., & Zandi, K. (2015). Antiviral potential of algae polysaccharides isolated from marine sources: A review. BioMed Research International, 2015. 10.1155/2015/825203. - PMC - PubMed
    1. Aliasgharzadeh, A., Dehghan, P., Gargari, B. P., & Asghari-Jafarabadi, M. (2015). Resistant dextrin, as a prebiotic, improves insulin resistance and inflammation in women with type 2 diabetes: A randomised controlled clinical trial. British Journal of Nutrition, 113(2), 321–330. 10.1017/S0007114514003675. - PubMed
    1. Alkhatib, A., Tsang, C., Tiss, A., Bahorun, T., Arefanian, H., Barake, R., … Tuomilehto, J. (2017). Functional foods and lifestyle approaches for diabetes prevention and management. Nutrients, 9(12), 1310. 10.3390/nu9121310. - PMC - PubMed
    1. Alongi, M., & Anese, M. (2021). Re-thinking functional food development through a holistic approach. Journal of Functional Foods, 81, 104466. 10.1016/j.jff.2021.104466.
    1. Andrew, M., & Jayaraman, G. (2020). Marine sulfated polysaccharides as potential antiviral drug candidates to treat Corona virus disease (COVID-19). January. - PMC - PubMed

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