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Case Reports
. 2022 Oct-Dec;6(4):169-171.
doi: 10.1016/j.ihjccr.2022.09.008. Epub 2022 Oct 7.

Mechanical prosthetic valve thrombosis after ChAdOx1-nCoV-19 vaccination: A case report

Akash Jain  1 , Varun Marimuthu  1 , Nagamani Alur  1
Affiliations
Case Reports

Mechanical prosthetic valve thrombosis after ChAdOx1-nCoV-19 vaccination: A case report

Akash Jain et al. IHJ Cardiovasc Case Rep. 2022 Oct-Dec.

Abstract

The ChAdOx1 nCoV-19 adenoviral vector-based vaccine was the first to be approved against COVID-19 in India. Vaccine induced thrombotic thrombocytopenia (VITT) is a rare but serious adverse effect of the ChAdOx1 nCoV-19 vaccine, causing widespread thrombosis and thrombocytopenia. A 22-year-old patient, who had undergone mechanical mitral valve replacement, presented to us one week after administration of 1st dose of the ChAdOx1 nCoV-19 Coronavirus vaccine with acute prosthetic heart valve thrombosis (PVT). Laboratory investigations revealed thrombocytopenia and high D-Dimer levels, suggestive of probable VITT. In this report, we highlight the importance of identification of VITT as a cause of PVT and discuss management options.

Keywords: Coronavirus; Heart valve diseases; Thrombosis; Vaccines.

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Conflict of interest statement

No conflict of interest.

Figures

Fig. 1
Fig. 1
Bedside Transthoracic echocardiogram with impaired mobility of the bileaflet mechanical prosthesis A) In systole, showing the immobile valve leaflets (white arrowhead) B) In diastole.
Fig. 2
Fig. 2
A) Increased mitral valve gradients B) Doppler of the tricuspid regurgitation jet showing elevated pulmonary artery systolic pressures.
Fig. 3
Fig. 3
A and B) Fluoroscopy showing impaired valve leaflet mobility (video 2).
See this image and copyright information in PMC

References

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